Results 141 to 150 of about 53,341 (352)
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
USE OF THE PRINCIPLE OF PRESUMPTION OF INNOCENCE IN THE SYSTEM OF ADMINISTRATIVE JUSTICE
, 2023 V. V. MUSHENOK, V. A. OKHRIMENKO
openalex +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
The rationale for detention in the Jordanian Code of criminal procedure: A comparative study with French law. [PDF]
Heliyon, 2022 Abuanzeh A.
europepmc +1 more source
The Reversal of the Burden of Proof; Between Presumption of Innocence and Presumption of Guilt
, 2023 Roni Efendi +4 more
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The Relevance of Judicial Procedure for Economic Growth [PDF]
It has been argued that procedural formalism undermines economic efficiency by fostering rent-seeking and corruption. We challenge this view by arguing that a number of judicial procedures foster economic growth by increasing the predict-ability of court
Bernd Hayo, Stefan Voigt
core
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Who Must Presume Whom to Be Innocent of What? [PDF]
, 2013 This paper considers the roles that may be played by a “presumption of innocence” outside the criminal trial — a presumption that reflects a general principle of civic trust.
Duff, Antony
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
The Reasonable Doubt Rule and the Meaning of Innocence [PDF]
, 1989 Although the presumption of innocence is universally acknowledged as central to the Anglo-American accusatorial system, considerable controversy surrounds how far the presumption of innocence should be extended through the requirement that the state ...
Sundby, Scott E.
core +2 more sources