Results 71 to 80 of about 58,278 (391)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

THE PRESUMPTION OF INNOCENCE AS A FUNDAMENTAL HUMAN RIGHT IN THE BRAZILIAN CONSTITUTION AND ITS APPLICATION BY THE SUPREME FEDERAL COURT

Revista Eletrônica do Curso de Direito da UFSM, 2018
This article investigates the historical formation of the presumption of innocence and its establishment in international norms of protection of Human Rights such as the Universal Declaration and the American Convention.
Samyra Haydêe Dal Farra Naspolini, Vladmir Oliveira da Silveira   +1 more
doaj   +1 more source

Presumption of innocence and ensuring proof of guilt in criminal proceedings

Uzhhorod National University Herald. Series: Law
The presumption of innocence is an important bastion against miscarriages of justice and abuse of power. It guarantees that individuals will not be punished without solid and legally established evidence of their guilt.
A. R. Marchenko
semanticscholar   +1 more source

Сприяння захисту (Favor defensionis) [PDF]

, 2011
В статті розглядаються правила сприяння захисту, що засновані на принципі презумпції невинуватості. (The article deals with the rules of promoting of the protection based on the principle of presumption of ...
Попелюшко, В. (V. Popeliushko )
core  

Immigration Law\u27s Missing Presumption [PDF]

, 2023
The presumption of innocence is a foundational concept in criminal law but is completely missing from quasi-criminal immigration proceedings. This Article explores the relevance of a presumption of innocence to removal proceedings, arguing that ...
Marouf, Fatma
core  

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

ASAS PRESUMPTION OF INNOCENCE DALAM PERLINDUNGAN HAK ASASI MANUSIA SEBAGAI LANDASAN KEADILAN

Journal Presumption of Law, 2022
The existence of the principle of presumption of innocence is important both from the point of material criminal law and criminal procedural law, especially from the point of view of human rights.
Aji rahman Halim
doaj   +1 more source

The Guilty Mind [PDF]

, 2009
The doctrine of mens rea can be expressed in this way: MRP: If A is culpable for performing phi, then A performs phi intentionally in circumstances in which it is impermissible to perform phi. The Sermon on the Mount suggests the following principle: SMP:
Mann, William E.
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source