Results 81 to 90 of about 167,430,696 (282)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

The PRESUMPTION of INNOCENCE in ADMINISTRATIVE JURISDICTION

open access: yes, 2021
The presumption of innocence is accepted by its position in all international and regional human rights treaties as a standard of fair trials, which like that Continental Law System.
Çayan, Gökhan
core  

The Connection Reasons for Deprivation of Inheritance and Removal from Inheritance Have With Presumption of Innocence

open access: yesİstanbul Hukuk Mecmuası
Presumption of innocence and the right not to be criminalized constitute fundamental rights enshrined in the Turkish Constitution and the European Convention on Human Rights. In principle, violating the presumption of innocence in private law proceedings
Barış Demirsatan
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Could the Presumption of Innocence Protect the Guilty? [PDF]

open access: yesCriminal Law and Philosophy, 2012
At criminal trial, we demand that those accused of criminal wrongdoing be presumed innocent until proven guilty beyond any reasonable doubt. What are the moral and/or political grounds of this demand? One popular and natural answer to this question focuses on the moral badness or wrongness of convicting and punishing innocent persons, which I call the ...
openaire   +1 more source

Observance of the presumption of innocence principle in Latvia

open access: yes, 2023
Bakalaura darba tēma ir “Nevainīguma prezumpcijas principa ievērošanas aktualitātes Latvijā”. Bakalaura darba mērķis ir noskaidrot, vai nevainīguma prezumpcija nodrošina privāto tiesību juridiskām personām un fiziskajām personām no nevainīguma ...
Bērziņš, Niklāvs
core  

Considerations Regarding the Observance of the Presumption of Innocence in the Media

open access: yesEIRP Proceedings, 2009
The presumption of innocence, the right of privacy, of an intimate and a family life, the freedomof speech, officials, the deontological code of the journalist Abstract: In the context of the Rule of Law, amodern governing guarantees to anyone the ...
Sandra Gradinaru
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

REGULATING SUSPECT DISPLAY IN PRESS CONFERENCES: SAFEGUARDING HUMAN RIGHTS AND THE PRESUMPTION OF INNOCENCE

open access: yesAl-Adl
Press conferences involving suspects are frequently justified as mechanisms for ensuring accountability within law enforcement. However, these press conferences pose significant risks to the presumption of innocence and may lead to violations of human ...
Adam Ilyas, Maman Sudirman
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

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