Results 221 to 230 of about 18,388 (292)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Stereotypic beliefs dominate reversal learning. [PDF]

Sci Rep
Morgan MG, Golubickis M, Jalalian P, Sharma Y, Selvaraj ES, Rule NO, Macrae CN.   +6 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Magnetic dipole effects on unsteady nanofluid flow over a curved surface. [PDF]

Discov Nano
Ramzan M, Arshad S, Shahmir N, Alkhrijah Y, Barakat NS, Saeed AM, Koh WS.   +6 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

A novel distributed gradient algorithm for composite constrained optimization over directed network. [PDF]

Sci Rep
Ou M, Zhang H, Yan Z, Yang Z, Ran H.
europepmc   +1 more source

Optimizing trauma-focused treatments to address guilt and shame: Clinical considerations and strategies. [PDF]

J Trauma Stress
Wells SY, Davis BC, Wachen JS, Silva ME, Norman SB.   +4 more
europepmc   +1 more source

The Imperative of Involving Nurses When Reviewing Psychiatric Medication: a Qualitative Study of Implementing Physician-Led Medication Reviews for Psychiatric Outpatients With Diabetes. [PDF]

Basic Clin Pharmacol Toxicol
Christensen JFMM, Christensen EMM, Christensen U, Düring S, Jürgens G.   +4 more
europepmc   +1 more source

Private by default: reasonable expectations in secondary uses of patient data. [PDF]

Med Law Rev
Mourby M.
europepmc   +1 more source