British Journal of Clinical Pharmacology, EarlyView.Aims This study aimed to analyse clinical trial initial submissions received by the MHRA between February 2019 and October 2023. Methods Data on submissions were extracted from the clinical trials unit data bank. The primary end‐point was the type of clinical trial initial submissions.
Andrea Manfrin +4 more
wiley +1 more source
JMIR Public Health and SurveillanceBackgroundThe worldwide incidence of preterm births is increasing, and the risks of adverse outcomes for preterm infants significantly increase with shorter gestation, resulting in a substantial socioeconomic burden.
Huazhang Miao +4 more
doaj +1 more source
The case of late preterm birth: sliding forwards the critical window for cognitive outcome risk [PDF]
, 2015 Many survivors of preterm birth experience neurodevelopmental disabilities, such as cerebral palsy, visual and hearing problems. However, even in the absence of major neurological complications, premature babies show significant neuropsychological and ...
Mento, Giovanni, Nosarti, Chiara
core +1 more source
Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora [PDF]
, 2002 Objective: The purpose of this study was to determine whether the microbial hydrolytic enzymes, sialidase and prolidase, and immunoglobulin A against the Gardnerella vaginalis cytolysin (anti-Gvh IgA) increase the risk for early preterm birth ( 6434 ...
Agnew, K +6 more
core +1 more source
Utilising Deep Learning and Genome Wide Association Studies for Epistatic-Driven Preterm Birth Classification in African-American Women [PDF]
arXiv, 2018 Genome Wide Association Studies (GWAS) are used to identify statistically significant genetic variants in case-control studies. GWAS typically use a p-value threshold of 5 x 10-8 to identify highly ranked single nucleotide polymorphisms (SNPs). However, evidence has shown that many of these are, in fact, false positives.
arxiv
Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy [PDF]
, 2013 BACKGROUND: Preterm birth confers a high risk of adverse long term health outcomes for survivors, yet the underlying molecular mechanisms are unclear.
Alicia Oshlack +9 more
core +3 more sources
Alternating Loss Correction for Preterm-Birth Prediction from EHR Data with Noisy Labels [PDF]
arXiv, 2018 In this paper we are interested in the prediction of preterm birth based on diagnosis codes from longitudinal EHR. We formulate the prediction problem as a supervised classification with noisy labels. Our base classifier is a Recurrent Neural Network with an attention mechanism.
arxiv
Preterm birth after loop electrosurgical excision procedure (LEEP). how cone features and microbiota could influence the pregnancy outcome [PDF]
, 2018 OBJECTIVE: In the last years, the mean age of women who underwent cervical treatment for high-grade cervical intraepithelial neoplasia (CIN 2-3) is similar to the age of women having their first pregnancy.
Caserta, D. +12 more
core +2 more sources
“Ears of the Lynx” Sign on Brain MRI in Siblings With Spastic Paraplegia: A Case Report
Annals of the Child Neurology Society, EarlyView.ABSTRACT Background Hereditary spastic paraplegia (HSP) is a rare, clinically and genetically heterogenous condition that selectively affects the terminal segment of the descending corticospinal tract of the lumbar spine area, causing lower extremity spastic weakness with or without associated complex neurological symptoms.
Qingqing Wang, Manikum Moodley
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Over 10 million children in the world have epilepsy, with an unknown cause in half of the cases. The gut microbiome has been associated with various neurological disorders, and certain drugs greatly disturb the microbiome. Our aim was to study the association of prenatal and childhood exposure (before the age of two) to antibiotics, proton pump ...
Unnur Gudnadottir +4 more
wiley +1 more source