Results 141 to 150 of about 6,109,166 (291)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Prevalence of depression among infertile couples in Iran: A meta-analysis study [PDF]

, 2013
Background: Several studies have been conducted in Iran in order to investigate the prevalence of depression among infertile couples. However, there is a remarkable diversity among the results.
Keramat, A., Masoumi, S.Z., Moosavi, S.A., Poorolajal, J.   +3 more
core   +1 more source

High Prevalence of Gut Microbiota Colonization with Broad-Spectrum Cephalosporin Resistant Enterobacteriaceae in a Tunisian Intensive Care Unit [PDF]

, 2016
Elaa Maamar, Sana Ferjani, Ali Jendoubi, Samia Hammami, Zaineb Hamzaoui, Laure Mayonnove-Coulange, Mabrouka Saïdani, Aouatef Kammoun, Amel Rehaiem, Salma Ghedira, Mohamed Houissa, Ilhem Boutiba-Ben Boubaker, Amine Slim, Véronique Dubois   +13 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Prevalence of Depression among School-going Adolescents in an Urban Area of Bihar, India

, 2017
Kunal Jha, Satyajeet Kumar Singh, Santosh Kumar Nirala, Chandramani Kumar, Pragya Kumar, Neeraj Aggrawal   +5 more
openalex   +1 more source

Very high epilepsy prevalence in rural Southern Rwanda: The underestimated burden of epilepsy in sub‐Saharan Africa [PDF]

, 2023
Ieme Garrez, Dirk E. Teuwen, Fidèle Sebera, Sylvestre Mutungirehe, Arlène Ndayisenga, Delphine Kajeneza, Georgette Umuhoza, Jeannine Kayirangwa, Uta E. Düll, Peter Dedeken, Paul Boon   +10 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Prevalence of potentially inappropriate medication and its correlates in elderly hospitalized patients: A cross-sectional study based on Beers criteria

, 2020
Malika Arora, Rishabh Sharma, Parveen Bansal, Ravinder Garg, Ravi Ranjan, Rakesh Kumar   +5 more
openalex   +1 more source

Prevalence of High-Burden Medical Conditions Among Young and Middle-Aged Adults With Pediatric-Onset Medical Conditions: Findings From US Private and Public Administrative Claims Data [PDF]

, 2019
Daniel G. Whitney
openalex   +1 more source