Results 121 to 130 of about 4,121,422 (285)

Basic principles of genetics and genetic counselling

Indian Pacing and Electrophysiology Journal
Genetic counselling and testing is a fast growing field in modern medicine. Genetic analysis can aid in the diagnosis, treatment, management and prevention of (genetic) diseases in patients.
Nina J. Beelen, Jitendra Vohra, Job A.J. Verdonschot   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A Hemodynamic Echocardiographic Approach to Disease Severity and Prognosis in Transthyretin Amyloid Cardiomyopathy

JACC: Advances
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) causes heart failure and poor outcomes. Prognostic stratification is fundamental, yet validated staging systems rely exclusively on biomarkers, neglecting structural and functional cardiac ...
Matteo Serenelli, MD, Anna Cantone, MD, Aldostefano Porcari, MD, Marco Pozzan, MD, Marco Merlo, MD, Gianfranco Sinagra, MD, Gabriele Guidi Colombi, MD, Beatrice Dal Passo, MD, Federico Sanguettoli, MD, Matteo Arzenton, MD, Daniele Maio, MD, Martina Vitali, MD, Giulia Casolari, MD, Jacopo Bonini, MD, Alberto Cipriani, MD, Laura De Michieli, MD, Donato Mele, MD, Giulio Sinigiani, MD, Daniela Tomasoni, MD, Marco Metra, MD, Rita Pavasini, MD, Simone Biscaglia, MD, Gianluca Campo, MD   +22 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Estimating the prevalence of osteoporosis in Australia [PDF]

, 2014
This report presents information about the prevalence and impact of osteoporosis in Australians aged 50 and over. Summary Osteoporosis, a common condition among older people, causes bones to become weak.

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CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Fabry Disease Screening in Patients with Idiopathic HCM or LVH: Data from the Multicentric Nationwide F-CHECK Study

Biomedicines
Background/Objectives: Fabry disease (FD) is a rare X-linked disease caused by the deficient activity of the enzyme α-galactosidase A. Cardiac involvement is particularly critical, often determining the disease prognosis.
Raquel Machado, Inês Fortuna, Sílvia Sousa, Catarina Costa, João Calvão, Ana Filipa Amador, Patrícia Rodrigues, Dulce Brito, Marta Vilela, Natália António, Vanessa Lopes, Cristina Gavina, Ana Sofia Correia, Conceição Queirós, Alexandra Toste, Alexandra Sousa, Ricardo Fontes-Carvalho, André Lobo, Inês Silveira, Janete Quelhas-Santos, Elisabete Martins   +20 more
doaj   +1 more source

Chlamydia Prevalence Monitoring Project 2000 report

"The Centers for Disease Control and Prevention's (CDC) Chlamydia Prevalence Monitoring Project is a collaborative effort among Regional Infertility Prevention Projects, STD project areas, state epidemiologists and public health laboratory directors, the

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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Brugada syndrome in the forensic field: what do we know to date?

Frontiers in Cardiovascular Medicine
Brugada Syndrome is a cardiac genetic entity associated with an elevated risk of life-threatening arrhythmias, making accurate and prompt diagnosis vital to prevent lethal outcomes.
Oscar Campuzano, Oscar Campuzano, Oscar Campuzano, Simone Grassi, Estefanía Martínez-Barrios, Estefanía Martínez-Barrios, Estefanía Martínez-Barrios, Andrea Greco, Andrea Greco, Andrea Greco, Vincenzo Arena, Georgia Sarquella-Brugada, Georgia Sarquella-Brugada, Georgia Sarquella-Brugada, Georgia Sarquella-Brugada, Georgia Sarquella-Brugada, Antonio Oliva   +16 more
doaj   +1 more source