Results 101 to 110 of about 4,121,422 (285)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prevalence of Lens Opacities in India: The INDEYE Study [PDF]

, 2008
PurposeTo describe the prevalence of lens opacities in older people in India. MethodsPeople aged 60 years and older identified using random cluster-sampling in 2 study centres in north and south India, attended an eye examination.
Ravindran, RD, Maraini, G, Vashist, P, Fletcher, AE, Krishnan, T, Camparini, M, Fitzpatrick, KE, Chakravarthy, U, John, N, Murthy, GVS   +9 more
core   +2 more sources

Understanding the chemistry of temperate exoplanet atmospheres through experimental and numerical simulations

Astronomy & Astrophysics
Context. Characterizing temperate exoplanet atmospheres remains challenging due to their small size and low temperatures. Recent JWST observations provide valuable data, but their interpretation has led to diverging conclusions, highlighting the ...
Sohier O., Jaziri A. Y., Vettier L., Chatain A., Drant T., Carrasco N.   +5 more
doaj   +1 more source

Prevalence of Chagas disease in Latin-American migrants living in Europe: a systematic review and meta-analysis. [PDF]

, 2015
BACKGROUND: Few studies have assessed the burden of Chagas disease in non-endemic countries and most of them are based on prevalence estimates from Latin American (LA) countries that likely differ from the prevalence in migrants living in Europe. The aim
Muñoz Jose, Elisa Sicuri, Muñoz, J, Sicuri, Elisa, de Lazzari Elisa, Joaquim Gascon, Ana Requena-Méndez (101960), Joaquim Gascón (91277), Moore, David AJ, Moore, David A. J., de Lazzari, Elisa, Elisa de Lazzari, de Lazzari, E, Michael Brown, Brown, Michael, Lazzari, Elisa de, Moore David A. J., Requena-Méndez, A, Jose Muñoz, Sicuri, E, David A. J. Moore (81163), Muñoz, Jose, Ana Requena-Méndez, Gascon Joaquim, Gascón i Brustenga, Joaquim, Moore, DA, David A J Moore, Aldasoro, Edelweiss, José Muñoz (91279), Requena-Méndez Ana, Aldasoro Edelweiss, Requena-Méndez, Ana, Sicuri Elisa, Gascon, Joaquim, Michael Brown (219384), Brown Michael, Edelweiss Aldasoro, Edelweiss Aldasoro (288004), Gascon, J, Elisa De Lazzari (672963), Aldasoro, E, Elisa Sicuri (247271), Brown, M   +42 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Unique Features of Cardiovascular Involvement and Progression in Children with Marfan Syndrome Justify Dedicated Multidisciplinary Care

Journal of Cardiovascular Development and Disease
Marfan syndrome (MIM: # 154700; MFS) is an autosomal dominant disease representing the most common form of heritable connective tissue disorder. The condition presents variable multiorgan expression, typically involving a triad of cardiovascular, eye ...
Anwar Baban, Giovanni Parlapiano, Marianna Cicenia, Michela Armando, Alessio Franceschini, Concettina Pacifico, Arianna Panfili, Gaetano Zinzanella, Antonino Romanzo, Adelaide Fusco, Martina Caiazza, Gianluigi Perri, Lorenzo Galletti, Maria Cristina Digilio, Paola Sabrina Buonuomo, Andrea Bartuli, Antonio Novelli, Massimiliano Raponi, Giuseppe Limongelli   +18 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Appropriate time interval to update ambiguous genetic diagnosis in inherited arrhythmogenic syndromes

iScience
Summary: Genetic analysis identified the cause of the disease in inherited arrhythmogenic syndromes. A clinically actionable genetic diagnosis requires an accurate interpretation following the current guidelines. Practically half of the genetic diagnoses
Estefanía Martínez-Barrios, Andrea Greco, Sergi Cesar, Carles Díez-López, José Cruzalegui, Nuria Díez-Escuté, Patricia Cerralbo, Fredy Chipa, Irene Zschaeck, Simone Grassi, Antonio Oliva, Norma Balderrábano, Rocío Toro, Georgia Sarquella-Brugada, Oscar Campuzano   +14 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The contribution of genetics to the understanding and management of cardiomyopathies: Part 2

Revista Portuguesa de Cardiologia
Cardiomyopathies may present as a manifestation of various inherited syndromes. Recognizing the rarity and diagnostic challenges of syndromic and metabolic cardiomyopathies is crucial, as their identification holds significant implications for targeted ...
Isabel Cardoso, Mafalda Melo, Pedro Brás, José Miguel Viegas, Inês Almeida, Sofia Nunes, Inês Custódio, Conceição Trigo, Sérgio Laranjo, Rafael Graça, Rui Cruz Ferreira, Mário Oliveira, Sílvia Aguiar Rosa, Diana Antunes   +13 more
doaj   +1 more source