Results 111 to 120 of about 4,121,422 (285)

Is the HCV-HIV co-infection prevalence amongst injecting drug users a marker for the level of sexual and injection related HIV transmission?

, 2013
BACKGROUND: Amongst injecting drug users (IDUs), HIV is transmitted sexually and parenterally, but HCV is transmitted primarily parenterally. We assess and model the antibody prevalence of HCV amongst HIV-infected IDUs (denoted as HCV-HIV co-infection ...
?, ?, Martin, Natasha K, Strathdee, Steffanie, Beattie, Tara, Vickerman, Peter, EMCDDA Collaborative Group, Jarlais, Don Des, Wiessing, Lucas, Roy, Anuradha, Hickman, Matthew   +9 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Editorial: Proceedings and predictions in cardiac amyloidosis: unsolved mysteries and challenges for the future

Frontiers in Medicine, 2023
Aldostefano Porcari, Aldostefano Porcari, Aldostefano Porcari, Gianfranco Sinagra, Gianfranco Sinagra, Julian D. Gillmore   +5 more
doaj   +1 more source

Cognitive Improvement After Stroke: Prevalence and Trend During the First Three Months

Cerebral Circulation - Cognition and Behavior
Introduction: With similar estimates at 3 and 12 months after stroke, 4 out of 10 individuals have cognitive impairment that does not match the criteria for dementia.
Maede Sadat Etesami, Jūratė Šaltytė Benth, Elisabeth Kliem, Siri Weider, Knut Hestad, Ramune Grambaite   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Multiple Chemical Sensitivity: an Italian prevalence multicentric survey

Frontiers in Public Health
BackgroundMultiple Chemical Sensitivity (MCS) is a multisystem environmental disorder triggered by exposure to chemical agents at concentrations below toxicological thresholds.
Giovanni Genovese, Caterina Elisabetta Rizzo, Antonio Mistretta, Antonio Mistretta, Francesco Leonforte, Raffaele Squeri, Carlo Signorelli, Cristina Genovese, the Italian prevalence group   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Blood Biomarkers Predict 10-Year Clinical Outcomes in Adult Patients With Congenital Heart Disease

JACC: Advances
Background: The adult congenital heart disease (ACHD) population is growing and risk prediction is important to predict adverse outcome and consult patients during their lifecourse.
Paul M. Hendriks, MSc, MD, Annemien E. van den Bosch, MD, PhD, Laurie W. Geenen, MSc, MD, PhD, Vivan J.M. Baggen, MD, PhD, Jannet A. Eindhoven, MD, PhD, Robert M. Kauling, MD, Judith A.A.E. Cuypers, MD, PhD, Eric Boersma, PhD, Jolien W. Roos-Hesselink, MD, PhD   +8 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source