Results 51 to 60 of about 5,497,401 (351)

Preventing type 2 diabetes mellitus in Qatar by reducing obesity, smoking, and physical inactivity: mathematical modeling analyses. [PDF]

, 2019
BACKGROUND: The aim of this study was to estimate the impact of reducing the prevalence of obesity, smoking, and physical inactivity, and introducing physical activity as an explicit intervention, on the burden of type 2 diabetes mellitus (T2DM), using ...
A Abdullah, A Alhazmi, A Pan, Abdulla O. Al-Hamaq, AJ Al-Quwaidhi, C Hawkes, C Willi, D Aune, DP Guh, G Li, J Lindstrom, J Lindstrom, J Lindstrom, JC Lagarias, JM Borys, Julia A. Critchley, Katie G. El-Nahas, L Chen, Laith J. Abu-Raddad, M Chiu, Martin O’Flaherty, NM Abu-Rmeileh, O Saidi, SF Awad, Susanne F. Awad, The Lancet Diabetes E, VS Malik, WC Knowler   +27 more
core   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Helicobacter pylori virulence factors in duodenal ulceration: A primary cause or a secondary infection causing chronicity [PDF]

, 2006
Reports from countries with a high prevalence of Helicobacter pylori. (H pylori) infection do not show a proportionately high prevalence of duodenal ulceration, suggesting the possibility that H pylori cannot be a primary cause of duodenal ulceration. It
Hobsley, M, Holton, J, Tovey, FI
core   +1 more source

PREVALENCE OF SCURVY. [PDF]

The Lancet
n ...
openaire   +2 more sources

Prevalence of congenital amusia [PDF]

European Journal of Human Genetics, 2016
Congenital amusia (commonly known as tone deafness) is a lifelong musical disorder that affects 4% of the population according to a single estimate based on a single test from 1980. Here we present the first large-based measure of prevalence with a sample of 20 000 participants, which does not rely on self-referral.
Peretz, Isabelle, Vuvan , Dominique
openaire   +4 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

HCV treatment for prevention among people who inject drugs: Modeling treatment scale-up in the age of direct-acting antivirals. [PDF]

, 2013
UNLABELLED: Substantial reductions in hepatitis C virus (HCV) prevalence among people who inject drugs (PWID) cannot be achieved by harm reduction interventions such as needle exchange and opiate substitution therapy (OST) alone. Current HCV treatment is
Aitken, Allen, Berg, Burns, Cohen, Cohen, Cornish, Dahari, Dimova, Dore, Gane, Grebely, Grebely, Hagan, Hallinan, Harris, Health Protection Scotland and the University of the West of Scotland, Hellard, Hellard, Hickman, Innes, Iverson, Iverson, Jacobson, Kemp, Kim, Kimber, Kirwan, Lindenburg, Lindenburg, Liu, Liu, Ly, Maher, Martin, Martin, Martin, Mathers, McCaw, McInnes, Mehta, Micallef, Mondelli, Nelson, Nosyk, O'Keefe, Poordad, Poordad, Quinn, Shepard, Stoove, Sweeting, Turner, Vickerman, Vickerman, Wood, Zeiler   +56 more
core   +5 more sources

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

The horizon problem for prevalent surfaces [PDF]

Math. Proc. Cambridge Philos. Soc., 151, (2011), 355-372, 2011
We investigate the box dimensions of the horizon of a fractal surface defined by a function $f \in C[0,1]^2 $. In particular we show that a prevalent surface satisfies the `horizon property', namely that the box dimension of the horizon is one less than that of the surface.
arxiv   +1 more source

Cardiac Rehabilitation for Fontan Circulation Patients: A Systematic Review, and Meta-Analysis

Medicina
Background and Objectives: Despite advances in the surgical management of patients with Fontan circulation, their exercise capacity and quality of life remain significantly impaired.
Luna van de Ven, Ana Clara Félix, Joana Suarez, Jorge Dias, Fátima F. Pinto, Sérgio Laranjo   +5 more
doaj   +1 more source