Results 71 to 80 of about 311,710 (149)

Editorial: Proceedings and predictions in cardiac amyloidosis: unsolved mysteries and challenges for the future

Frontiers in Medicine, 2023
Aldostefano Porcari, Aldostefano Porcari, Aldostefano Porcari, Gianfranco Sinagra, Gianfranco Sinagra, Julian D. Gillmore   +5 more
doaj   +1 more source

Blood Biomarkers Predict 10-Year Clinical Outcomes in Adult Patients With Congenital Heart Disease

JACC: Advances
Background: The adult congenital heart disease (ACHD) population is growing and risk prediction is important to predict adverse outcome and consult patients during their lifecourse.
Paul M. Hendriks, MSc, MD, Annemien E. van den Bosch, MD, PhD, Laurie W. Geenen, MSc, MD, PhD, Vivan J.M. Baggen, MD, PhD, Jannet A. Eindhoven, MD, PhD, Robert M. Kauling, MD, Judith A.A.E. Cuypers, MD, PhD, Eric Boersma, PhD, Jolien W. Roos-Hesselink, MD, PhD   +8 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Multiple Chemical Sensitivity: an Italian prevalence multicentric survey

Frontiers in Public Health
BackgroundMultiple Chemical Sensitivity (MCS) is a multisystem environmental disorder triggered by exposure to chemical agents at concentrations below toxicological thresholds.
Giovanni Genovese, Caterina Elisabetta Rizzo, Antonio Mistretta, Antonio Mistretta, Francesco Leonforte, Raffaele Squeri, Carlo Signorelli, Cristina Genovese, the Italian prevalence group   +8 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Basic principles of genetics and genetic counselling

Indian Pacing and Electrophysiology Journal
Genetic counselling and testing is a fast growing field in modern medicine. Genetic analysis can aid in the diagnosis, treatment, management and prevention of (genetic) diseases in patients.
Nina J. Beelen, Jitendra Vohra, Job A.J. Verdonschot   +2 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Fabry Disease Screening in Patients with Idiopathic HCM or LVH: Data from the Multicentric Nationwide F-CHECK Study

Biomedicines
Background/Objectives: Fabry disease (FD) is a rare X-linked disease caused by the deficient activity of the enzyme α-galactosidase A. Cardiac involvement is particularly critical, often determining the disease prognosis.
Raquel Machado, Inês Fortuna, Sílvia Sousa, Catarina Costa, João Calvão, Ana Filipa Amador, Patrícia Rodrigues, Dulce Brito, Marta Vilela, Natália António, Vanessa Lopes, Cristina Gavina, Ana Sofia Correia, Conceição Queirós, Alexandra Toste, Alexandra Sousa, Ricardo Fontes-Carvalho, André Lobo, Inês Silveira, Janete Quelhas-Santos, Elisabete Martins   +20 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source