Results 111 to 120 of about 13,680,867 (312)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Survey of status quo of quality of life of empty nester in Lanzhou city
Huli yanjiu, 2016 Objective：To know about the status quo of quality of life of empty nester in Lanzhou city,so as to provide a theoretical basis for carrying out the intervention for improving the quality of life of the empty nester in Lanzhou.Methods： The multistage ...
李芳 +4 more
doaj
Prevalence Rate and Risk Factors of Sexual Assault Among University Students in the Netherlands. [PDF]
J Interpers Violence, 2023 Wellum AK +5 more
europepmc +1 more source
Citation: 'prevalence rate' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.14948 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Survey of prevalence of PICC induced upper limb venous thrombosis in cancer patients
Huli yanjiu, 2015 AbstractObjective：To know about the prevalence,cause and risk factors of PICC associated thrombus in cancer patients,to provide references for the prevention and control of PICC associated thrombus in cancer patients.Methods：All hospitalized patients ...
成芳 +7 more
doaj
Frontiers in Public HealthObjectiveTo analyze the changes in the burden of colorectal cancer in China and globally from 1990 to 2021, and to explore the disease burden across different age groups and sexes by integrating projected data from 2022 to 2036.
Yulai Yin, Xiaoyu Zhang
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source