Results 161 to 170 of about 7,991,089 (298)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.

Cell, 2017
Irina Ingold, C. Berndt, S. Schmitt, Sebastian G. Doll, G. Poschmann, Katalin Buday, A. Roveri, Xiao-Xiao Peng, Florencio Porto Freitas, Tobias Seibt, Lisa Mehr, M. Aichler, A. Walch, D. Lamp, M. Jastroch, S. Miyamoto, W. Wurst, F. Ursini, Elias S. J. Arnér, Noelia Fradejas-Villar, U. Schweizer, H. Zischka, J. P. Friedmann Angeli, M. Conrad   +23 more
semanticscholar   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Coronary Plaque Burden in South Asian Adults: Insights From the DILWALE Registry. [PDF]

JACC Adv
Rashid AM, Srikanth S, Tavanaei N, Gupta S, Patel K, Prasad T, Spitz J, Satish P, Kalra D, Khan MS, Alsaid A, Kulkarni A.   +11 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Report of the Royal Commission to inquire into the causes of and measures taken to prevent the bush fires of January, 1939 and to protect life and property and the measures to be taken to prevent bush fires in Victoria and to protect life and property in

, 1939
Commissioner: Leonard E.B. Stretton.; Publication no. 2 - 6912/39.; Electronic reproduction. Canberra, A.C.T.
Victoria. Royal Commission to Inquire into the Causes of and Measures Taken to Prevent the Bush Fires of January 1939.
core  

Cardiovascular Disease Incidence and Risk Factor Contributions in Adults Aged 45 to 59 Years With Low 10-Year and High 30-Year Risk: Findings From REGARDS. [PDF]

Circ Popul Health Outcomes
Satish M, Safford MM, Ringel JB, Jumonville G, Quezada-Pinedo HG, Walters RW, Kini V, Hardy ST, Levitan EB, Muntner P, Colantonio LD.   +10 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source