Results 81 to 90 of about 6,866,993 (305)
Editor comment: Focus on cardiovascular prevention [PDF]
European Journal of Preventive Cardiology, 2021 Geza Halasz +2 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Asymmetric perception of gains vs non-losses and losses vs non-gains: The causal role of regulatory focus [PDF]
Recent studies show that, while losses loom larger than equivalent non-gains, gains loom larger than equivalent non-losses. This finding, at odds with the loss aversion principle, has been interpreted within the framework of regulatory focus theory.
Simona Sacchi, Luca Stanca
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Contents of Hopes and Duties: A Linguistic Analysis
Frontiers in Psychology, 2018 People in a prevention focus tend to view their goals as duties and obligations, whereas people in a promotion focus tend to view their goals as hopes and aspirations.
Leigh Ann Vaughn
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Focus Ireland annual report 1999.
, 2000 Focus Ireland believes that everyone has the right to a place they can call home and to live a life with dignity at an acceptable standard of living. Sadly, however, this is not always the case for many people in Ireland despite the sometimes seemingly
Focus Ireland
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
New directions in sexual assault prevention
, 2003 The central question that faces all of us who are committed to non-violence is how can we prevent sexual assault. This is a question that has been a concern of feminist politics for over a century and more recently for the last three decades.
Carmody, Moira
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Prevention of copd exacerbations. Focus on dual bronchodilators
Медицинский совет, 2018 COPD exacerbations occur in almost all patients, and half of patients in the Russian Federation (52%) have two or more exacerbations per year or require urgent admission to hospital.
V. V. Arkhipov
doaj +1 more source