Results 211 to 220 of about 167,559,018 (302)

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

The social and economic burden of retinopathy of prematurity: screening, treatment, and health policy perspectives in a transnational narrative review. [PDF]

Front Pediatr
Canepa ME, Serafino M, Striano P, Ramenghi LA.   +3 more
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Cost-Effectiveness of the Smaller-Incision New Generation Implantable Miniature Telescope for Late-Stage Age-Related Macular Degeneration. [PDF]

Ophthalmol Sci
Basile M, Valentini I, Calosci EM, Sciomenta I, Di Brino E, Rumi F, Barca F, De Angelis L, Savastano A, Francione G, Sasso P, Toro Mario D, Giglio R, Rizzo S.   +13 more
europepmc   +1 more source

Single‐Sensor Vibration Sensing in Anisotropic Composites Enabled by Disordered Metasurfaces

Advanced Science, EarlyView.
This work develops a single‐sensor vibration sensing (SSVS) framework that integrates disordered metasurfaces with compressive sensing. Comprehensive numerical and experimental validations demonstrate that, by manipulating anisotropic guided wave propagation through metasurfaces, the proposed SSVS framework enables high‐fidelity multi‐source vibration ...
Jianjie Zhang, Lanhe Xu, Zhongzheng Zhang, Yongbo Li, Eric Li, Asoke K. Nandi, Bing Li   +6 more
wiley   +1 more source

Knowledge and Attitudes Toward Trachoma Among Final-Year Clinical Medicine Students in Dar es Salaam, Tanzania: A Descriptive Cross-Sectional Study. [PDF]

J Trop Med
Marishamu LE, Masuki I, Masuki H, Mushi VP, Mhina C, Mosenene NS, Mafwiri M.   +6 more
europepmc   +1 more source

Refractive error blindness in older africans.

, 2013
Sherwin, Justin C, Courtright, Paul, Hassan, Kunle, Cook, Colin, Lewallen, Susan, Mathenge, Wanjiku, Kalua, Khumbo   +6 more
core   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Vision at risk: assessing women's knowledge of trachoma in Jordan: A cross-sectional survey study. [PDF]

Medicine (Baltimore)
Abdulmannan DM, Naser AY.
europepmc   +1 more source

THE PREVENTION OF BLINDNESS. [PDF]

Journal of the American Public Health Association, 1911
openaire   +2 more sources