Results 41 to 50 of about 167,559,018 (302)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The prevention of blindness : report of a WHO Study Group [meeting held in Geneva from 6 to 10 November 1972] [PDF]

, 1973
hun published by: Budapest : Akadémiai Nyomda. 1973Russian version of nos. 516-530 bound together (barcode no.
World Health Organization, WHO Study Group on the Prevention of Blindness   +1 more
core  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial [PDF]

, 2011
Glaucoma is the leading cause of irreversible blindness. Although primary open-angle glaucoma is more common, primary angle-closure glaucoma (PACG) is more likely to result in irreversible blindness.
Burr, JM, Vale L., Azuara-Blanco, Augusto; id_orcid, Gla, EIA-C, Friedman, D, Jimmy Lai, Cochran C., Ramsay C., Nolan, W, Cochran, C, Ramsay, C, Quayyum Zahidul, Azuara-Blanco A., Aung T., McDonald, A, Cochran, Claire, AzuaraBlanco, A, Zahidul Quayyum, McPherson, Gladys, Ramsay, Craig, Foster P., Friedman David, Lai Jimmy, Norrie, John David Taylor, Cochran Claire, McPherson Gladys, McDonald, Alison, Vale, L, Ramsay Craig, Winnie Nolan, Alison McDonald, Burr J.M., Burr, Jennifer M., Aung Tin, Paul Chew, null null, Azuara-Blanco, A, Quayyum, Z, McPherson, G, Azuara-Blanco, Augusto, Burr, Jennifer M, Quayyum, Zahidul, Effectiveness in Angle-closure Glaucoma of Lens Extraction (EAGL, Lai, Jimmy, Augusto Azuara-Blanco, Tin Aung, Foster, P, Norrie, John, Chew Paul, Burr Jennifer M, Foster, Paul, Effectiveness in Angle-closure Glaucoma of Lens Extraction (EAGLE) Study Group, Claire Cochran, David Friedman, Chew, Paul, Nolan, Winnie, Vale, Luke, Friedman D., Lai, J, Friedman, David, Chew P., McPherson G., Foster Paul, Norrie John, Norrie J., John Norrie, Lai J., Aung, T, Aung, Tin, Vale Luke, Craig Ramsay, Gladys McPherson, Paul Foster, McDonald A., McDonald Alison, Jennifer M Burr, Norrie, J, Chew, P, Nolan Winnie, Luke Vale, Quayyum Z., Nolan W., Azuara-Blanco Augusto   +82 more
core   +2 more sources

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Tackling inequality and inequity in eye health: can the SDGs help us?

Community Eye Health Journal, 2016
The Sustainable Development Goals (SDGs) were adopted at the United Nations (UN) General Assembly in September 2015. They are a set of goals and targets that all UN member states have committed to achieving: ‘to end poverty, protect the planet, and ...
Zoe Gray
doaj  

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Blindness and visual impairment due to age-related cataract in sub-Saharan Africa: a systematic review of recent population-based studies. [PDF]

, 2013
AIM: We aimed to evaluate age-related cataract as a contributor to blindness and visual impairment (VI) in sub-Saharan Africa (SSA). METHODS: A systematic review of population-based studies published between 2000 and October 2012.
Sherwin, Justin C, Bastawrous, Andrew, Dean, William H   +2 more
core   +1 more source

Inequality and inequity in eye health

Community Eye Health Journal, 2016
According to the 2010 Global Burden of Disease (GBD) study, the global prevalence of blindness (age-standardised) has declined from 0.60% in 1990 to 0.47% in 2010.
Johannes Trimmel
doaj