Results 161 to 170 of about 202,953,608 (275)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Fast re-establishment of QoS with NSIS protocols in mobile networks
, 2007 Re-establishment of the QoS after a Mobile Node handover must be done as quickly as possible in order to reduce degradation or interruption of QoS, especially when realtime applications are used.
MOLENDINI, Simone +3 more
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Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
CDC\u2019s suicide prevention resource for action
Preventing Suicide is a PriorityCDC\u2019s Suicide Prevention Resource for Action (Prevention Resource) details the strategies with the best available evidence to reduce suicide.
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Junior recruit's handbook / Junior Recruit Training Establishment, H.M.A.S. Leeuwin.
, 1975 0642930961 (ISBN). First published, 1961.; Electronic reproduction. Canberra, A.C.T.
Australia. Department of Defence. Directorate of Recruiting. Junior Recruit Training Establishment. H.M.A.S. Leeuwin.
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
National Center for Injury Prevention and Control Division of Violence Prevention annual report 2011
The Centers for Disease Control and Prevention (CDC) began studying patterns of violence in the early 1980\u2019s after the US Surgeon General identified violent behavior as a key public health priority.
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source