Results 101 to 110 of about 11,113,149 (315)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Maintenance Optimization for Repairable Deteriorating Systems under Imperfect Preventive Maintenance
Mathematics, 2019 This study deals with the preventive maintenance optimization problem based on a reliability threshold. The conditional reliability threshold is used instead of the system reliability threshold.
Juhyun Lee, Byunghoon Kim, Suneung Ahn
doaj +1 more source
Solving Colorado's Health Professionals Shortage: Initial Lessons Learned From the Health Professions Initiative Evaluation [PDF]
, 2007 Gives an overview of the trust's 2005-08 Health Professions Initiative to address expected shortages in all healthcare professions, its impact so far, and the strategies grantees are implementing to help strengthen the training ...
Kaia Gallagher, Tanya Beer
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
[Preventive activities in primary care]. [PDF]
Aten Primaria, 2022 González Natal MN.
europepmc +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
European Journal of General PracticePrevention is a fundamental aspect of the work of general practitioners (GPs) and family doctors (FDs); however, its implementation poses significant challenges due to conflicting guidelines, time constraints, competing demands, and equity concerns. This
Veerle Piessens +4 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Home Accident Prevention Activities [PDF]
Public Health Reports (1896-1970), 1952 F S, KENT, M, PERSHING
openaire +2 more sources
Prices and protocols in public health care [PDF]
The author tries to derive price and rationing rules for public health facilities. He highlights the effect on these rules of different assumptions about the objectives of government (health versus welfare), the limits of available policy instruments ...
Hammer, Jeffrey S.
core