Results 141 to 150 of about 782,060 (307)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploring the relationship between cognitive abilities and motor performance in athletes with intellectual disabilities

Frontiers in Sports and Active Living
IntroductionBasketball practice for athletes with intellectual disabilities (ID) is an ancient activity that stimulates cognitive and motor performance domains.
Luca Cavaggioni, Luca Cavaggioni, Damiano Formenti, Linda Casalini, Francesco Granito, Chiara Magro, Andrea Manente, Simona Canton, Nicola Lovecchio, Paolo Castiglioni, Paolo Castiglioni, Giampiero Merati, Giampiero Merati   +12 more
doaj   +1 more source

Final Report of the Evaluation of the San Mateo County Children's Health Initiative [PDF]

, 2008
Summarizes key findings from a five-year evaluation of the county's Children's Health Initiative -- its outreach and enrollment efforts, the impact on children enrolled in the Healthy Kids program, areas for improvement, and financing ...
Ariel Klein, Dana Hughes, Embry Howell, Genevieve M. Kenney, Louise Palmer   +4 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Preventive activities of association in cardiovascular disease prevention

Acta clinica Croatica, 2014
A major activity of Association is professional and educational symposium „Stampar days“ which consists of three parts and makes an unique component with appointed goal of prevention of cardiovascular diseases with public health campaign. One component presents active involvement of educated members of Asscociation that have been taken short version of
Barišić, Ivan, Vukoja, Ivan, Romić, Marija, Relić, Danko, Ivković, Jana   +4 more
openaire   +3 more sources

[Analysis of the situation, evaluation and improvement proposals of the Preventive Activities and Health Promotion Program (PAPPS)]. [PDF]

Aten Primaria, 2020
Martín-Carrillo Domínguez P, Martín-Rabadán Muro M, González-Lama J, Romero-Rodríguez E, Pérula de Torres LÁ, Camarelles Guillén F.   +5 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Context-based task ontologies for clinical guidelines [PDF]

, 2004
Evidence-based medicine relies on the execution of clinical practice guidelines and protocols. A great deal of of effort has been invested in the development of various tools which automate the representation and execution of the recommendations ...
Ciccarese, Paolo, Kumar, Anand, Piazza, Matteo, Smith, Barry   +3 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An approach to health and safety in E.U. forestry operations – Hazards and preventive measures [PDF]

Forestry in general and logging in particular continue to be among the three most hazardous sectors in European countries. The aim of this article is to characterize health and safety problems and solutions in E.U.
José Miquel Cabeças
core   +1 more source