Results 101 to 110 of about 1,123,280 (346)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Oral rehydration of malnourished children with diarrhoea and dehydration: A systematic review [version 3; referees: 2 approved]

Wellcome Open Research, 2017
Background: Diarrhoea complicates over half of admissions to hospital with severe acute malnutrition (SAM). World Health Organization (WHO) guidelines for the management of dehydration recommend the use of oral rehydration with ReSoMal (an oral ...
Kirsty A. Houston, Jack G. Gibb, Kathryn Maitland   +2 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Solving Colorado's Health Professionals Shortage: Initial Lessons Learned From the Health Professions Initiative Evaluation [PDF]

, 2007
Gives an overview of the trust's 2005-08 Health Professions Initiative to address expected shortages in all healthcare professions, its impact so far, and the strategies grantees are implementing to help strengthen the training ...
Kaia Gallagher, Tanya Beer
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Building a Prevention Clinic at the Northport VA to Improve Pneumonia Vaccination Numbers

AJPM Focus
Introduction: Pneumonia vaccination rates have increased to >60% over the last 20 years. At the Long Island, New York, Northport VA Hospital, pneumonia vaccination data from 2021 showed a vaccination rate of 68.55%.
Namita Akolkar, MD, MPH, Danielle K. Craigg, MD, MPH, Lisa Fisher, MD   +2 more
doaj   +1 more source

Characteristic of FINDRISC Score and Association with Diabetes Development in 6-Year Follow-Up in PURE Poland Cohort Study

Vascular Health and Risk Management, 2021
Katarzyna Zatońska,1 Alicja Basiak-Rasała,1 Katarzyna Połtyn-Zaradna,1 Dorota Różańska,2 Maciej Karczewski,3 Maria Wołyniec,1 Andrzej Szuba4 1Department of Social Medicine, Wroclaw Medical University, Wroc&lstrok ...
Zatońska K, Basiak-Rasała A, Połtyn-Zaradna K, Różańska D, Karczewski M, Wołyniec M, Szuba A   +6 more
doaj  

Realizing Health Reform's Potential: How the Affordable Care Act Will Strengthen Primary Care and Benefit Patients, Providers, and Payers [PDF]

, 2011
Examines issues in primary care and outlines the 2010 healthcare reform law's provisions to strengthen it, including temporary hikes in Medicare and Medicaid payments and support for innovations in care delivery and primary care workforce ...
Georgette Lawlor, Melinda Abrams, Rachel Nuzum, Stephanie Mika   +3 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source