Results 101 to 110 of about 739,700 (305)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Predators drive community structure in coral reef fish assemblages
Ecosphere, 2015 The importance of top‐down effects in structuring ecological communities has been widely debated by ecologists. One way in which to examine these processes is to study the secondary effects of predator removal on communities. This study examined the role
A. E. Boaden, M. .J Kingsford
doaj +1 more source
PICES Press, Vol. 11, No. 2, July 2003 [PDF]
, 2003 Cover [pdf, 1.2 Mb] PICES Science Board and Governing Council hold their first joint meeting [pp. 1-3] [pdf, 0.2 Mb] 3rd International Zooplankton Production Symposium [pp.
core
Does the invasive plant Elymus athericus modify fish diet in tidal salt marshes? [PDF]
, 2005 The invasion of Mont-Saint-Michel Bay salt marshes (France) by a grass species (Elymus athericus) has led to important changes in vegetation cover, which is likely to modify the habitat for many invertebrates.
Feunteun, Eric +7 more
core +3 more sources
Long‐Term Demography of Spotted Hyena (
Ecology and EvolutionABSTRACTInterspecific competition has strongly shaped the evolution of large carnivore guilds. In Africa, the lion (Panthera leo) and spotted hyena (Crocuta crocuta, hereafter hyena) exert direct and indirect competitive impacts on each other and on subordinate guild members. The impacts of competition on demography are complex and not well understood.
S. Martens +10 more
openaire +4 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Factors affecting methylmercury biomagnification by a widespread aquatic invertebrate predator, the phantom midge larvae Chaoborus [PDF]
, 2012 MeHg biomagnification by the phantom midge Chaoborus in relation to MeHg concentrations in their prey and its migratory behavior was investigated in two Canadian Precambrian Shield lakes.
Aldamman, Lama +5 more
core +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Whale-watching and Herring Fishing: Joint or Independent Production? [PDF]
The effects of "localized depletion" of a pelagic fishery (herring) on a non-extractive marine activity (tourism) are investigated. Proponents of the localized depletion theory claim that intense fishing effort can lead to areas that are unsuitable for ...
Lee, Min-Yang A.
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source