Results 131 to 140 of about 739,700 (305)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

High carnivore richness despite human pressure and prey depletion in the south-west of the Kavango–Zambezi Transfrontier Conservation Area

Oryx
Transfrontier conservation landscapes, such as the Kavango–Zambezi Transfrontier Conservation Area (KAZA TCA) in southern Africa, play a crucial role in preserving global biodiversity and promoting the sustainable development of local communities ...
Stijn Verschueren, Tim Hofmann, Mikael Kakove, Hans Bauer, Bogdan Cristescu, Laurie Marker   +5 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Effects of starvation on energy density of juvenile chum salmon (Oncorhynchus keta) captured in marine waters of Southeastern Alaska [PDF]

, 2010
We conducted laboratory starvation experiments on juvenile chum salmon (Oncorhynchus keta) captured in the neritic marine waters of northern Southeast Alaska in June and July 2003. Temporal changes in fish energy density (whole body energy content [WBEC]
Ferguson , Emily A., Orsi, Joseph A., Sturdevant, Molly V.   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Benefits of Spatial Regulation in a Multispecies System [PDF]

Spatial heterogeneity in multispecies systems affects both ecological interactions and the composition of harvest. A bioeconomic model is used to analyze the nonselective harvest of two stocks with generalized ecological interaction and different ...
Herrera, Guillermo E.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The cascading impact of an invasive snake on arthropod communities

Ecological Processes
Background The depletion of birds and mammals by invasive snakes is known to trigger top-down trophic cascades in recipient ecosystems. However, the indirect effects of island reptile depletion by invasive snakes remain largely unexplored, despite ...
Julien C. Piquet, Borja Maestresalas, Marta López-Darias   +2 more
doaj   +1 more source

Exposing illegal hunting and wildlife depletion in the world's largest tropical country through social media data

Conservation Biology
Globally, illegal sport hunting can threaten prey populations when unregulated. Due to its covert nature, illegal sport hunting poses challenges for data collection, hindering efforts to understand the full extent of its impacts. We gathered social media
H. E. El Bizri, M. A. Oliveira, Aline Pessutti Rampini, Simon Knoop, J. E. Fa, Lauren Coad, T. Morcatty, G. Massocato, A. Desbiez, J. Campos‐Silva, Daniel Zani La Laina, José Mauricio Barbanti Duarte, R. S. Barboza, Zilca Campos, M. B. Da Silva, Sarah Mângia, Daniel J. Ingram, J. Bogoni   +17 more
semanticscholar   +1 more source