Results 91 to 100 of about 1,043,331 (298)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

The Utah Manipulation and Locomotion of Large Objects (MeLLO) Data Library

Bioengineering
The purpose of this paper is to provide researchers with a description of a data library representing human interaction with medium- to large-sized objects in everyday life. The library includes motion capture data characterizing human and object motion,
Nathaniel G. Luttmer, Nathan I. Baum, Josue Flores-Gonzalez, John M. Hollerbach, Mark A. Minor   +4 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Price Theory in Ancient India [PDF]

, 2023
Kalyani Marla
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Optimal mean arterial pressure and its objective statistical associations with clinical outcomes and multimodal monitoring cerebral physiology: A systematic scoping review

Physiological Reports
Optimal mean arterial pressure (MAPopt), also known as optimal arterial blood pressure (ABPopt), represents a patient‐specific blood pressure range at which cerebral autoregulation is most intact.
Rakibul Hasan, Angela Buchel, Kevin Y. Stein, Tobias Bergmann, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Isuru Herath, Noah Silvaggio, Mansoor Hayat, Jaewoong Moon, Frederick A. Zeiler   +10 more
doaj   +1 more source

Continuous personalized cerebrovascular reactivity-based physiologic metrics in neurocritical care: a narrative review of the current landscape, limitations, and future directions

Frontiers in Physiology
Over the past several decades, significant progress has been made in our ability to achieve guideline-based cerebral physiologic targets for the management of moderate-to-severe traumatic brain injury (TBI). However, despite these advancements, there has
Kevin Y. Stein, Kevin Y. Stein, Logan Froese, Rakibul Hasan, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Tobias Bergmann, Abrar Islam, Noah Silvaggio, Mansoor Hayat, Frederick A. Zeiler, Frederick A. Zeiler, Frederick A. Zeiler, Frederick A. Zeiler   +13 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Artifact management methodologies for arterial blood pressure signals: A systematic scoping review of human and animal literature

Physiological Reports
Arterial blood pressure (ABP) is a broadly measured vital signal used to monitor cardiovascular health through raw signal and derived metrics. Artifacts are a pervasive issue, resulting in a declined utility of the signal.
Tobias Bergmann, Nuray Vakitbilir, Xue Nemoga‐Stout, Amanjyot Singh Sainbhi, Kevin Y. Stein, Noah Silvaggio, Rakibul Hasan, Jaewoong Moon, Mansoor Hayat, Logan Froese, Frederick A. Zeiler   +10 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source