Results 91 to 100 of about 550,112 (248)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Utah Manipulation and Locomotion of Large Objects (MeLLO) Data Library

Bioengineering
The purpose of this paper is to provide researchers with a description of a data library representing human interaction with medium- to large-sized objects in everyday life. The library includes motion capture data characterizing human and object motion,
Nathaniel G. Luttmer, Nathan I. Baum, Josue Flores-Gonzalez, John M. Hollerbach, Mark A. Minor   +4 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Optimal mean arterial pressure and its objective statistical associations with clinical outcomes and multimodal monitoring cerebral physiology: A systematic scoping review

Physiological Reports
Optimal mean arterial pressure (MAPopt), also known as optimal arterial blood pressure (ABPopt), represents a patient‐specific blood pressure range at which cerebral autoregulation is most intact.
Rakibul Hasan, Angela Buchel, Kevin Y. Stein, Tobias Bergmann, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Isuru Herath, Noah Silvaggio, Mansoor Hayat, Jaewoong Moon, Frederick A. Zeiler   +10 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Artifact management methodologies for arterial blood pressure signals: A systematic scoping review of human and animal literature

Physiological Reports
Arterial blood pressure (ABP) is a broadly measured vital signal used to monitor cardiovascular health through raw signal and derived metrics. Artifacts are a pervasive issue, resulting in a declined utility of the signal.
Tobias Bergmann, Nuray Vakitbilir, Xue Nemoga‐Stout, Amanjyot Singh Sainbhi, Kevin Y. Stein, Noah Silvaggio, Rakibul Hasan, Jaewoong Moon, Mansoor Hayat, Logan Froese, Frederick A. Zeiler   +10 more
doaj   +1 more source

Continuous personalized cerebrovascular reactivity-based physiologic metrics in neurocritical care: a narrative review of the current landscape, limitations, and future directions

Frontiers in Physiology
Over the past several decades, significant progress has been made in our ability to achieve guideline-based cerebral physiologic targets for the management of moderate-to-severe traumatic brain injury (TBI). However, despite these advancements, there has
Kevin Y. Stein, Kevin Y. Stein, Logan Froese, Rakibul Hasan, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Tobias Bergmann, Abrar Islam, Noah Silvaggio, Mansoor Hayat, Frederick A. Zeiler, Frederick A. Zeiler, Frederick A. Zeiler, Frederick A. Zeiler   +13 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source