Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
K.W. Taylor,A History of the Vietnamese. Cambridge: Cambridge University Press, 2013, xvi + 696 pp. ISBN 9780521699150. Price: GBP 29.99 (paperback). [PDF]
, 2014 Hans Hågerdal
openalex +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Perception of market and pricing among the sixteenth century Muslim scholars [PDF]
The present paper investigates the perception of market and mechanism of pricing among the sixteenth century Muslim scholars, a period hitherto unexplored.
Islahi, Abdul Azim
core +1 more source
[Review of] Sterling Plumpp, ed. Somehow We Survive: An Anthology of South African Writing [PDF]
, 1989 Somehow We Survive takes its title from an included poem by Dennis Brutus and is a collection of poems written in English by non-white South Africans.
Bruner, David K.
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
History-Based Price Discrimination with Imperfect Information Accuracy and Asymmetric Market Shares [PDF]
, 2021 Stefano Colombo +2 more
openalex +2 more sources
The Methodology of Forming Prices of Farm Produce, History of Price Formation in the USSR [PDF]
, 1970 I. Lukinov, Lukinov, I.
openalex +1 more source
Stock Broker Summary History Analisys Volume Value Frequency And Price Accumulation
, 2023 Evan Zovinul +3 more
openalex +2 more sources