Results 171 to 180 of about 4,934,009 (308)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Covid-19 Pandemisi Sürecinde E-Ticaret Faaliyetleri ve E-Ticaretin İktisadi Etki Analizi: Türkiye Üzerine Değerlendirme

open access: yesHitit Ekonomi ve Politika Dergisi
Dünya Sağlık Örgütü tarafından pandemi olarak ilan edilen Covid-19 salgını Türkiye’de de 2020 yılı Mart ayında ilk kez görülmüştür. Bir sağlık krizi olarak Wuhan şehrinde yayılmaya başlayan kriz kısa sürede küresel bir kamu sağlığı krizine dönüşmüştür ...
Elif Zehra Yılmaz, Suzan Odabaşı
doaj  

Fish is food--the FAO's fish price index. [PDF]

open access: yesPLoS One, 2012
Tveterås S   +7 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

New Evidence on Outlet Substitution Effects in Consumer Price Index Data [PDF]

open access: yes
In this paper we provide new and detailed evidence on the impact on the U.S. CPI of the appearance and growth of new types of product outlets. Using actual CPI microdata for 2002-2007, we find that the changing mix of outlets had a statistically ...
John S. Greenlees, Robert McClelland
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Price Indexes for Medical Care Goods and Services: An Overview of Measurement Issues [PDF]

open access: yes
We review in considerable detail the conceptual and measurement issues that underlie construction of medical care price indexes in the U.S., particularly the medical care consumer price indexes (MCPIs) and medical-related producer price indexes (MPPIs ...
Zvi Griliches   +4 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Biases in cross-space comparisons through cross-time price indexes: The case of Russia [PDF]

open access: yes
Lacking data on price levels across locations (countries, national regions, etc.) for cross-space comparisons, researchers resort to local consumer price indexes (CPIs) over time to evaluate these levels.
Gluschenko, Konstantin
core  

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