Results 61 to 70 of about 1,887 (235)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Further study of Late Devonian seed plant Cosmosperma polyloba: its reconstruction and evolutionary significance

BMC Evolutionary Biology, 2017
Background The earliest seed plants in the Late Devonian (Famennian) are abundant and well known. However, most of them lack information regarding the frond system and reconstruction.
Le Liu, Deming Wang, Meicen Meng, Jinzhuang Xue   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

RESISTÊNCIA NATURAL DA MADEIRA DE SABIÁ (Mimosa caesalpiniifolia Benth.) A CUPINS SUBTERRÂNEOS

Revista Caatinga, 2011
The objective of this research was to evaluate the wood natural resistance of Mimosa caesalpiniifolia Benth. of phenotypes (plants) with and without prickles to subterranean termite (Nasutitermes corniger Motsch.) in forced feeding and feeding preference
FRANCISCO HUGO HERMÓGENES DE ALENCAR, JUAREZ BENIGNO PAES, OLAF ANDREAS BAKKE, GIRLAINE SOUZA DA SILVA   +3 more
doaj  

Morphology, structure and ontogeny of trichomes of the grape genus (Vitis, Vitaceae)

Frontiers in Plant Science, 2016
Trichomes are widely distributed on surfaces of different organs in the grape genus Vitis and are of taxonomic utility. To explore the morphology, structure and ontogeny of Vitis trichomes, we investigated the diversity and distribution of trichomes in ...
Zhi-Yao eMa, Jun eWen, Stefanie M. Ickert-Bond, Long-Qing eChen, Xiu-Qun eLiu   +4 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Morphology of long axes and geometry of the tested rose prickles.

, 2015
The specified values are medians and lower and upper quartiles (in brackets). Number of samples are n = 36 (Rosa arvensis), n = 141 (Rosa arvensis ‘Splendens‘ type I) and n = 149 (Rosa arvensis ‘Splendens‘ type II).
Thomas Speck (52971), Kathrin Fiedler (832572), Friederike Gallenmüller (832570), Amélie Feus (832571)   +3 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Maximum force and maximum force/basal area measured at failure of the tested rose prickles.

, 2015
In the illustrations of force direction the stem apex is situated on the left and the stem base on the right. x indicates that testing with a traction force in this direction was not possible due to slippage of the Kevlar loop. Numbers below indicate the
Thomas Speck (52971), Kathrin Fiedler (832572), Friederike Gallenmüller (832570), Amélie Feus (832571)   +3 more
core   +1 more source