Results 51 to 60 of about 15,468 (196)

In Vivo Partial Cell Reprogramming With Yamanaka Factors Reduced Ischemic Brain Damage in Aging Mice

Aging Cell, Volume 25, Issue 11, November 2026.
Short‐term cyclic partial reprogramming with Yamanaka factors protects aged mice from ischemic brain injury, preserving cognitive function, myelin integrity, and neuronal density, supporting partial reprogramming as a promising neuroprotective intervention in aging.
Paula R. Mallavibarrena, Gerardo Martín‐López, Jorge Rodríguez‐Morales, Jesús Ávila, Félix Hernández, María José Pérez‐Álvarez   +5 more
wiley   +1 more source

How Safe is Prilocaine as a Local Anesthetic in Children Younger Than 2 Years of Age: A Case Series

Southern Clinics of Istanbul Eurasia, 2018
INTRODUCTION[|]Methemoglobinemia is an urgent condition requiring early diagnosis and treatment; it may be fatal if the methemoglobin (MetHb) level is greater than 70% and tissue oxygenation is impaired.
Merve Güllü, Nahide Haykır, Perran Boran, Gülnur Tokuç   +3 more
doaj   +1 more source

Topical Anesthetics Effectiveness in Management of Orthodontic Pain: A Systematic Review of Randomized Controlled Trials

Clinical and Experimental Dental Research, Volume 12, Issue 5, October 2026.
ABSTRACT Objectives Orthodontic treatment can be associated with pain, particularly during separator placement, appliance insertion, or activation. Topical anesthetics may offer a simple, locally applied alternative to systemic analgesics, but their effectiveness remains uncertain.
Qasim Khalid, Abbas Naseem, Waqas Naseem, Adnan Jehangir, Umar Hussain, Maryam Altuhafy, Junad Khan   +6 more
wiley   +1 more source

Methaemoglobinaemia secondary to topical lignocaine/prilocaine in a circumcised neonate

, 2000
The use of topical lignocaine/prilocaine (EMLA, Astra Pharmaceuticals, North Ryde, NSW, Australia) for pain relief for neonatal circumcision is becoming more prevalent.
Couper, R.
core   +1 more source

Hong Kong Poison Information Centre: Annual report 2022

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 5, October 2026.
Abstract Background The Hong Kong Poison Information Centre (HKPIC) has been providing consultation services to healthcare professionals and collecting epidemiological data on poisoning in Hong Kong since 2005. Objective To analyse and report the poisoning data from HKPIC in 2022.
Tin Yat Anthony Chow, Chi Keung Chan, Shan Liu, Sze Hong Ng, Man Li Tse   +4 more
wiley   +1 more source

The Role of Ultra‐Low‐Dose Naloxone as an Additive in Anesthesia and Nerve Block: A Systematic Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims In anesthesia and analgesia, opioids alone or in combination with local anesthetics (bupivacaine, lidocaine, and ropivacaine) have been investigated to prolong peripheral nerve blocks. Ultra‐low‐dose naloxone administration in local anesthetic solutions could lengthen sensory and motor blocks through enhanced opioid effects
Mohammadjavad Mehrabanian, Behrang Nooralishahi, Mehdi Dehghani Firoozabadi, Mohammad Sahebjam, Yekta Ghane, Homayoun Pishraft‐Sabet, Nazila Heidari, Akbar Shafiee   +7 more
wiley   +1 more source

Prilocaine-and Lidocaine-Induced Methemoglobinemia Is Caused by Human Carboxylesterase-, CYP2E1-, and CYP3A4-Mediated Metabolic Activation [PDF]

, 2020
Prilocaine and lidocaine are classified as amide-type local anesthetics for which serious adverse effects include methemoglobinemia. Although the hydrolyzed metabolites of prilocaine (o-toluidine) and lidocaine (2,6-xylidine) have been suspected to ...
Tatsuki Fukami, Miki Nakajima, Ryota Higuchi, Tsuyoshi Yokoi   +3 more
core  

Pharmacokinetics of Intravenous Melatonin in Preschool‐Aged Pediatric Surgical Patients

Pediatric Anesthesia, Volume 36, Issue 10, Page 1308-1315, October 2026.
ABSTRACT Background Melatonin may have several beneficial clinical effects in the perioperative setting. In children, it has been studied for preoperative anxiety, postoperative pain, and emergence delirium. Melatonin's pharmacokinetic profile is well‐known in adults, but data in young children are sparse.
Anne Louise de Barros Garioud, Arash Afshari, Lau Romlund Halgreen, Kristian Østergaard Nielsen, Lars Peter Kloster Andersen   +4 more
wiley   +1 more source

Shoulder‐Tip Pain After Laparoscopic Surgery: A Narrative Review of Intraperitoneal Anaesthesia

ANZ Journal of Surgery, Volume 96, Issue 10, Page 2772-2782, October 2026.
ABSTRACT Background and Aims Shoulder‐tip pain is a common and distressing side effect following laparoscopic surgery. Standard systemic analgesic regimens are used to manage postoperative pain but are often associated with side effects such as nausea and vomiting.
Jason Arsanious, Alice Osterwalder, Sarah K. Thompson   +2 more
wiley   +1 more source

Comparison of Hemodynamic Profiles and Onset and Offset of Motor and Sensory Blockade between 2% Hyperbaric Prilocaine and 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Scheduled Cesarean Sections: A Double-Blind, Randomized Clinical Trial

Bali Journal of Anesthesiology
Background: Hyperbaric prilocaine is claimed to have a more stable hemodynamic profile with a faster onset and faster recovery or offset for both motor and sensory blockade than bupivacaine.
Kristian Felix Wundiawan, Putu Agus Surya Panji, Wayan Suranadi, Made Gede Widnyana, Dewa Ayu Mas Shintya Dewi, I Gusti Agung Gede Utara Hartawan, Pontisomaya Parami, Tjahya Aryasa   +7 more
doaj   +1 more source