Results 171 to 180 of about 4,700,345 (286)

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Probable Primary Adrenal Insufficiency Associated With Granulomatous Adrenal Calcifications, Non-tuberculous Mycobacterial Ileitis, and Crohn's Disease: A Case Report. [PDF]

Cureus
Lozano Dubernard GM, Ruíz López PJ, Aguiar Hernández FI, López Gutiérrez J.   +3 more
europepmc   +1 more source

Cortisol Cutoffs for Adrenal Insufficiency Using Elecsys II: A Systematic Review

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Adrenal insufficiency (AI) is associated with increased risk of morbidity and mortality if improperly managed. Adrenocorticotrophin (ACTH) stimulation testing is the most widely used AI diagnostic test. Historically, a serum cortisol threshold of 500 nmol/L (18.1 µg/dL), derived using polyclonal assays, was widely used.
Sarah Haunton, Nicola Leppinen, Heather MacDonald, Rebecca A. Tobin, Raoul Rooman, Leanne M. Ward, Alexandra Ahmet, Utkarsh J. Dang   +7 more
wiley   +1 more source

Disseminated histoplasmosis presenting as primary adrenal insufficiency in an immunocompetent host in the United States: a case report. [PDF]

BMC Infect Dis
Kumar G, Zahid I, Lager C, Avner BS.
europepmc   +1 more source

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

Primary adrenal insufficiency resulting in diagnosis of rare <i>ABCD1</i> pathogenic variant in X-linked adrenoleukodystrophy. [PDF]

JCEM Case Rep
Jin A, Bhatnagar A, Bryant A, Soe K.
europepmc   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Continuous subcutaneous hydrocortisone infusion in pediatric primary adrenal insufficiency: a cohort study. [PDF]

Endocr Connect
Fouatih K, Trouvin MA, Lambert AS, Rothenbuhler A, Verdelet T, Lecoq AL, Bouligand J, Laddada L, Chappell K, Lopez M, Bouyacoub M, Yahia A, Haidar H, Trabado S, Linglart A, Bouvattier C, Ait Tayeb AEK.   +16 more
europepmc   +1 more source

Semaglutide for Treating Paediatric Craniopharyngioma‐Related Obesity: A Multicentre Case Series

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Obesity is a complication of childhood craniopharyngioma that remains difficult to treat. We investigated whether semaglutide was associated with a decrease in BMI among adolescents with craniopharyngioma‐related obesity. Material and Methods This multicentre retrospective study included 20 patients < 18 years old with craniopharyngioma ...
Joanne Dornberger, Pascal Barat, Karine Aouchiche, Kevin Perge, Carine Villanueva, Sarah Castets, Natacha Bouhours‐Nouet, Aurelie Donzeau, Lucie Levaillant, Cecile Teinturier, Rachel Reynaud, Ahlam Azar‐Kolakez, Laetitia Martinerie, Dulanjalee Kariyawasam, Regis Coutant   +14 more
wiley   +1 more source

Novel biomarkers to guide glucocorticoid replacement in primary adrenal insufficiency: a proof-of-concept study using copeptin-derived ratios. [PDF]

J Endocrinol Invest
Bima C, Campioni L, Berton AM, Sola C, Bergoglio B, Di Carlo MC, Ponzetto F, Settanni F, Ceccato F, Parasiliti-Caprino M, Giordano R.   +10 more
europepmc   +1 more source