Results 201 to 210 of about 55,893 (295)

Association Between Allostatic Load and Incident Colorectal Cancer—A Prospective Study in a Multiethnic Asian Population

open access: yesCancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Allostatic load (AL) reflects the cumulative physiological burden of chronic stress across cardiovascular, metabolic, immune, and renal systems. While AL has been implicated in cancer development, evidence in Asian populations remains limited.
Su Hyun Park   +6 more
wiley   +1 more source

Fruquintinib Plus TAS‐102 With or Without SBRT as Third‐ Or Later‐Line Therapy for Metastatic Colorectal Cancer: Preliminary Results From a Prospective Phase II Trial

open access: yesCancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Both fruquintinib and TAS‐102 monotherapies are guideline‐recommended for third‐line treatment of metastatic colorectal cancer (mCRC). This study aimed to analyze the preliminary outcomes of fruquintinib combined with TAS‐102, with or without stereotactic body radiation therapy (SBRT), as a third‐ or later‐line therapy for mCRC.
Yi Wang   +19 more
wiley   +1 more source

A Chinese X‐Linked Adrenoleukodystrophy Patient With Atypical Clinical Symptoms Contained an Undefined ABCD1 Mutation—A Case Report and Literature Review

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT X‐linked adrenoleukodystrophy (X‐ALD) is a genetic peroxisome disorder linked to ABCD1 mutation, characterized by rapid and complex clinical symptoms. We here report a case of X‐ALD manifesting solely as dysarthria, associated with an undefined mutation in the ABCD1 gene, underscoring the necessity of atypical clinical symptoms in X‐ALD ...
Fu‐Qing Zhang   +4 more
wiley   +1 more source

An Atypical Presentation of Tuberculous Ascites, Severe Hyponatremia, and Acute Kidney Injury in a Young Male

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT A 25‐year‐old male who had been in good health before presenting with right lower lobe pneumonia, severe hyponatremia (Na 117 mEq/L), distension, and reduced urine output. AKI secondary to acute glomerulonephritis (GN) or interstitial nephritis was suggested by the initial workup. He was discharged for outpatient nephrology follow‐up following
Bassem Al Hariri   +5 more
wiley   +1 more source

Skin Hyperpigmentation: An Under‐Recognized Dermatological Clue to Vitamin B12 Deficiency

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
Hyperpigmentation over the dorsal aspect of both hands, prominently involving the knuckles. ABSTRACT Cutaneous hyperpigmentation, an overlooked manifestation, can be an early sign of vitamin B12 deficiency. This case highlights symmetric pigmentation on the dorsum of hands and palms in a long‐term vegetarian.
Mahesh Mathur   +5 more
wiley   +1 more source

Fianlimab, a human lymphocyte activation gene‐3 monoclonal antibody, in combination with cemiplimab: Tumor‐specific expansion cohorts in advanced malignancies

open access: yesCancer, Volume 132, Issue 9, 1 May 2026.
Abstract Background The dose escalation phase of a first‐in‐human (FIH) study demonstrated acceptable safety and preliminary antitumor activity of fianlimab (anti‐lymphocyte activation gene‐3 [LAG‐3]) as monotherapy and in combination with cemiplimab (anti‐programmed cell death‐1 [PD‐1]). Here, the authors present safety and clinical activity data from
Tae Min Kim   +25 more
wiley   +1 more source

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