Results 31 to 40 of about 5,417,949 (300)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Anterior Lens Curvature Matters in the Course of Primary Angle Closure: An Analysis Based on Ultrasound Biomicroscopic Imaging

Journal of Ophthalmology, 2022
Purpose. To evaluate the effect of anterior lens curvature in primary angle closure (PAC) and find additional anatomical features of crystalline lens that may predispose primary angle closure to the acute course. Methods.
Tingting Liu, Mengwei Li, Xiaoxiao Chen, Zhenying Jiang, Xiangmei Li, Xinghuai Sun, Jiajian Wang, Yuhong Chen   +7 more
doaj   +1 more source

Impact of Phacoemulsification Surgery on Intraocular Pressure in Primary Angle-Closure Glaucoma

, 2012
Pur po se: To investigate whether primary phacoemulsification in acute primary angle closure glaucoma (APACG) and chronic primary angle closure glaucoma (CPACG) will lower intraocular pressure (IOP) or not.
Volkan Dayanır, Aykut Özdemir, Ahmet Kaplan, Esin Kırıkkaya   +3 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

New Insights in Primary Angle Closure Glaucoma

Delhi Journal of Ophthalmology, 2010
Primary angle closure glaucoma is one of the major causes for irreversible visual loss in Asia. In addition to pupillary block, lens induced mechanisms, plateau iris and supra-ciliary effusions are important contributing factors eluciadated by Ultrasound
Tanuj Dada, Gaurav Kumar, Lalit Tejwani, Vishal Arora, Meenakshi Wadhwani, Anita Panda   +5 more
doaj   +1 more source

A comparison of two approaches to managing acute primary angle closure in Asian eyes

, 2013
Henrietta Ho,1 Paul T Chew,2 Chelvin Sng,1,2 Huiqi Huang,1 Tin Aung,1,2 Shamira A Perera1,21Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; 2Yong Loo Lin School of Medicine, National University of Singapore and National ...
Chew P.T., Sng C., Chew PT, Aung T., Ho H., Perera S.A., Huang H, Huang H., Sng C, Perera SA, Ho H, Aung T   +11 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Incidence and characteristics of aqueous misdirection after glaucoma surgery in Chinese patients with primary angle-closure glaucoma

Eye and Vision, 2023
Background To report the incidence and clinical characteristics of aqueous misdirection (AM) after glaucoma surgery in Chinese patients with primary angle-closure glaucoma.
Haishuang Lin, Jiaqian Li, Xuanli Zheng, Rui Wan, Mengtian Zhou, Yutong Ding, Yiting Ji, Yanqian Xie, Clement C. Tham, Shaodan Zhang, Yuanbo Liang   +10 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source