Results 211 to 220 of about 6,908,138 (351)

Integration of Lifestyle Medicine Into Primary Care: A Comprehensive Review. [PDF]

Public Health Rep
Miller C.
europepmc   +1 more source

Chronic exertional compartment syndrome – unpicking a tricky diagnosis in primary care

, 2023
Ricardo Catumbela, D. M. Whittaker, Irfan Ahmed   +2 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Editorial: New trends in managing obesity in primary care. [PDF]

Front Med (Lausanne)
Mazzeti CMDS, Clark CCT, Rafacho BPM.
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Preparing for Accreditation Council for Graduate Medical Education–International accreditation: exploring approaches, insights and learning experiences through accreditation journey of residency program [PDF]

Korean Journal of Medical Education
Rahul Ramesh Bogam, Jihene Maatoug EP Maaloul, Syed Meraj Ahmed, Mohamed Hussameldin Mohamed Aabdien, Mohamed Iheb Bougmiza, Nagah Al Aziz Selim   +5 more
doaj   +1 more source

Detection of Frailty in Primary Care. [PDF]

Aging Med (Milton)
Forsyth D.
europepmc   +1 more source

The yield of routine laboratory examination in osteoporosis evaluation in primary care [PDF]

Thomas Merlijn, Karin M. A. Swart, Christy Niemeijer, Henriëtte E. van der Horst, Coen Netelenbos, Petra J. M. Elders   +5 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source