Results 221 to 230 of about 6,908,138 (351)

Natural course of subclinical hyperthyroidism In primary care in the Netherlands. [PDF]

Eur Thyroid J
Ursem SR, den Elzen WP, van den Berg JM, Boelen A, Elders PJM, Noordam R, Heijboer AC.   +6 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Patient perspectives on loneliness interventions in primary care: A qualitative study. [PDF]

Psychol Serv
Saulnier KG, Lapidos A, Jagusch J, Garland S, Harrod M, Pfeiffer PN.   +5 more
europepmc   +1 more source

Assessing a national policy on strengthening chronic care in primary care settings of a low-resource country using patients' perspectives.

, 2020
Paibul Suriyawongpaisal, Wichai Aekplakorn, Samrit Srithamrongsaw, Phanuwich Kaewkamjonchai   +3 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Brief behavioral intervention for chronic pain in integrated primary care: What are we waiting for?

Gregory P. Beehler, Michael Verile, Mandy Conrad, Dezarie Moskal   +3 more
openalex   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Application and challenges of DeepSeek in primary care in China. [PDF]

Front Public Health
Zhang J, Li D, Wang X, Wu Z, Lyu Q.
europepmc   +1 more source

Online Health Promotion to Reduce Cancer Risk: Lessons From Learning With Alaska’s Tribal Primary Care Providers

, 2018
Katie Cueva, Melany Cueva, Laura Revels, Michelle R. Hensel, Mark Dignan   +4 more
openalex   +1 more source