Results 121 to 130 of about 4,821,890 (183)
Chronic Hypobaric Hypoxia Modulates Primary Cilia Differently in Adult and Fetal Ovine Kidneys
Frontiers in Physiology, 2017 Hypoxic environments at high altitude have significant effects on kidney injury. Following injury, renal primary cilia display length alterations. Primary cilia are mechanosensory organelles that regulate tubular architecture.
Kiumars Shamloo +9 more
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Primary cilia defects causing mitral valve prolapse
Science Translational Medicine, 2019 Genetic variations in primary cilia genes cause defects during valve morphogenesis that can progress to mitral valve prolapse in the adult. DZIPping along to diagnosis Mitral valve prolapse is a common congenital abnormality that can cause severe ...
K. Toomer +49 more
semanticscholar +1 more source
Primary cilia and their role in cancer
Oncology Letters, 2019 Primary cilia are microtubule-based organelles that are expressed on almost all mammalian cells. It has become apparent that these structures are important signaling hubs that serve crucial roles in Wnt, hedgehog, extracellular signal-regulated kinase ...
M. Higgins, I. Obaidi, T. McMorrow
semanticscholar +1 more source
Redox Biology, 2019 The primary cilium, which protrudes from the cell surface, is associated with the pathogenesis of various diseases, including acute kidney injury (AKI). Primary cilium length dynamically changes during the progression of diseases.
Min Jung Kong +5 more
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Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression [PDF]
, 2017 Uromodulin (UMOD) mutations are responsible for three autosomal dominant tubulo-interstitial nephropathies including medullary cystic kidney disease type 2 (MCKD2), familial juvenile hyperuricemic nephropathy and glomerulocystic kidney disease.
Attanasio, Massimo +15 more
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Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
Neurobiology of Disease, 2021 Rong Ma +4 more
semanticscholar +1 more source
Pulmonary Circulation, 2018 Pulmonary arterial hypertension (PAH) is a syndrome characterized by progressive lung vascular remodelling, endothelial cell (EC) dysfunction, and excessive inflammation.
Anneloes Dummer +9 more
doaj +1 more source
The molecular structure of mammalian primary cilia revealed by cryo-electron tomography
Nature Structural & Molecular Biology, 2020 P. Kiesel +7 more
semanticscholar +1 more source
Cilia-mediated signalling in the embryonic nodes: A computational fluid-structure-protein interaction (FSPI) model [PDF]
, 2009 This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009) +3 more
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