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Mechanical stimulation of primary cilia
Frontiers in Bioscience, 2008The ciliary/flagellar system is perhaps unique in biology in that not only are biochemical manipulations used to elucidate the function, but physical manipulations as well. Thus, there is a considerable need to have an integrated physical-biochemical model of a cilium and its function.
Andrew, Resnick, Ulrich, Hopfer
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Analysis of Caveolin in Primary Cilia
2020Recent evidence has indicated that caveolins are localized at the base of primary cilia, which are microtubule-based sensory organelles present on the cell surface, and that Caveolin-1 (CAV1) plays important roles in regulating ciliary membrane composition and function.
Morthorst, Stine K. +3 more
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Isolation of Mammalian Primary Cilia
2013Primary cilia are microtubule-based organelles found on most types of cells in the human body. Although primary cilia were long thought to be vestigial remnants of motile cilia, it is now known that primary cilia play important roles in development and physiology, and defects of primary cilia cause a wide range of human disease symptoms, termed ...
Hiroaki, Ishikawa, Wallace F, Marshall
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Inversin, Wnt signaling and primary cilia
Differentiation, 2012Mutations of the ankyrin-repeat protein Inversin, a member of a diverse family of more than 12 proteins, cause nephronophthisis (NPH), an autosomal recessive cystic kidney disease associated with extra-renal manifestations such as retinitis pigmentosa, cerebellar aplasia and situs inversus.
Lienkamp, Soeren +2 more
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Mechanobiology of Primary Cilia
2010Within many mechanosensitive tissues and organs such as vascular endothelium, renal and liver epithelium, and bone, the cells residing within them are exposed to fluid flow. The process by which flow-induced mechanical loads are sensed by these cells and transduced into a biochemical signal is mostly unknown.
Ronald Y. Kwon +2 more
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Analyzing Primary Cilia by Multiphoton Microscopy
2009In this chapter, a technique is outlined for the use of immunohistochemistry (IHC) followed by multiphoton microscopy (MPM) for the analysis of incidence, length, and 3D orientation of the axoneme of the primary cilium. Although the application presented specifically emphasizes localizations in tenocytes and chondrocytes, the technique is applicable to
Cornelia E, Farnum +2 more
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Primary cilia of the corneal endothelium
American Journal of Anatomy, 1980AbstractA primary cilium is a normal component of every rabbit corneal endothelial cell, rather than being a rare or sporadic organelle, as previously believed. In common with other cilia of this type it possesses an axonemal organization of 9+0 which converts distally to 8+1; it occurs only one per cell; and the basal body is accompanied by a proximal
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Odontoblast primary cilia: facts and hypotheses
Cell Biology International, 2004AbstractOdontoblasts, the cells responsible for the dentine formation, are organized as a single layer of highly polarized and differentiated post‐mitotic cells along the interface between the dental pulp and the mineralized tubules. They lay down the physiological secondary dentine throughout the life of the teeth.
Henry, Magloire +3 more
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ADCY3, neuronal primary cilia and obesity
Nature Genetics, 2018Two new studies identify rare homozygous variants in ADCY3 that are causal for monogenic obesity in consanguineous families of Pakistani origin and are associated with increased risk of obesity in Greenlandic individuals. Greenlandic carriers of homozygous loss-of-function variants in ADCY3, and individuals from trans-ancestry studies with a burden of ...
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