Results 101 to 110 of about 5,447,793 (309)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Educational Partnership in Primary Education
Procedia - Social and Behavioral Sciences, 2015 AbstractThe purpose of this study is to highlight the need for educational partnerships in primary education in order to develop optimal educational process.The paper presents the results of a study conducted at two schools in Alexandria, who developed partnerships with educational authorities, institutions(medical units, police, church), local ...
openaire +1 more source
Primary Physical Education Teacher Educators’ Professional Learning [PDF]
, 2019 Pre-service teachers, teachers and teacher educators, are professionals continuously seeking knowledge to support and guide them in their work. This chapter explores, how initial teacher educators, and specifically Primary Physical Education Teacher Educators (PPETEs) learn as professionals.
openaire +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Review of Gaelic medium early education and childcare [PDF]
, 2010 The National Plan for Gaelic 2007-2012 contains ambitious targets for the expansion of Gaelic medium (GM) primary school education, aiming for 4000 children enrolled in P1 by 2021. GM early years education and childcare plays a crucial role in attracting
Carroll, Tessa +4 more
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Education for all and for life? : An introduction into primary school education in Senegal [PDF]
, 2011 Generally, school participation in Senegal has achieved a lot of progress in recent years. However, several problems remain to be tackled for further improvement. Still, too many children never attend a school.
Graef, Steffen, Gönsch, Iris
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
, 2008 This chapter discusses mathematics. It is part of a collection which examines educational practice and professional thinking from pre-school and primary, through secondary, further and higher education; and locates Scottish education within its social ...
Maclellan, Effie
core