Results 91 to 100 of about 4,191,972 (346)

Sensitivity of cosmic-ray experiments to ultra-high-energy photons: reconstruction of the spectrum and limits on the superheavy dark matter

, 2009
We estimate the sensitivity of various experiments detecting ultra-high-energy cosmic rays to primary photons with energies above 10^19 eV. We demonstrate that the energy of a primary photon may be significantly (up to a factor of ~ 10) under- or ...
G. Gelmini, G. I. Rubtsov, L. D. Landau, M. I. Pravdin, N. Sakaki, O. E. Kalashev, S. Baker, S. V. Troitsky, S. V. Troitsky, T. Pierog, W. H. Press, Z. T. Zatsepin   +11 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Rev-Changes in Primary Energy Use and CO2 Emissions—An Impact Assessment for a Building with Focus on the Swedish Proposal for Nearly Zero Energy Buildings

Energies, 2017
In the European Union’s Energy Performance of Buildings Directive, the energy efficiency goal for buildings is set in terms of primary energy use.
Mattias Gustafsson, Richard Thygesen, Björn Karlsson, Louise Ödlund   +3 more
doaj   +1 more source

Evaluation of Primary Energy from Photovoltaics for a Nearly Zero Energy Building (nZEB): A Case Study in Lithuania

Proceedings, 2020
The European Commission has set the target in the Energy Efficiency Directive (EED) to reduce EU primary energy consumption in 2020 by 20%. A crucial aspect of the overall assessment of energy saving measures that affect electricity demand is the primary
Rokas Tamašauskas, Jolanta Šadauskienė, Dorota Anna Krawczyk, Violeta Medelienė   +3 more
doaj   +1 more source

Comparison of AGASA data with CORSIKA simulation

, 1999
An interpretation of AGASA (Akeno Giant Air Shower Array) data by comparing the experimental results with the simulated ones by CORSIKA (COsmic Ray SImulation for KASCADE) has been made.
Barnett, Bird, Bird, Chiba, Dai, Dawson, Doi, Fletcher, Gaisser, Greisen, Greisen, Hayashida, Hayashida, Hayashida, Hayashida, Hillas, Kalmykov, Kasahara, Lawrence, M Nagano, Matsubara, Murzin, Nagano, Nagano, Ohoka, Sakaki, Shibata, Takeda, Takeda, Teshima, Yoshida, Zatsepin   +31 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Analysis of energy demand for low-energy multi-dwelling buildings of different configuration / Skirtingos konfigūracijos mažaenergių daugiabučių pastatų energijos poreikių tyrimas

Mokslas: Lietuvos Ateitis, 2014
To meet the goals established by Directive 2010/31/EU of the European Parliament and of the Council on the energy performance of buildings, the topics of energy efficiency in new and old buildings must be solved.
Giedrė Streckienė, Elena Polonis
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source