Results 121 to 130 of about 20,108,567 (392)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Possibilities and limits of reduced primary tillage in organic farming [PDF]

, 2002
In two organically cultivated field trials, located in Germany and Greece, effects of reduced primary tillage systems on root and shoot growth of cereals were investigated.
Dimitrios, Bilalis, Sidiras, Nikolaos, Ulrich, Köpke, Vakali, Christina   +3 more
core  

The M 4 Core Project with HST – III. Search for variable stars in the primary field★ [PDF]

, 2014
V. Nascimbeni, L. R. Bedin, Douglas C. Heggie, M. van den Berg, Mirek Giersz, G. Piotto, K. Brogaard, Andrea Bellini, A. P. Milone, R. Michael Rich, D. Pooley, Jay Anderson, Leonardo Úbeda, S. Ortolani, L. Malavolta, A. Cunial, A. Pietrinferni   +16 more
openalex   +1 more source

Asymmetric Patterns of Visual Field Loss in Primary Angle Closure Glaucoma, High Tension Glaucoma, and Normal Tension Glaucoma [PDF]

, 2021
Junhong Jiang, Cong Ye, Cong Zhang, Wenqing Ye, Xiaoyan Wang, Xiao Shang, Xiang Xu, Hongte Zhang, Shaodan Zhang, Jingwei Zheng, Jingjing Zuo, Jingjing Hu, Nathan Congdon, Fan Lü, Yuanbo Liang   +14 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

COVID-19 outbreak investigation among construction workers at a construction site in Harare, Zimbabwe February - March 2021 Amanda Sarah Thakataka, Joseph

Journal of Interventional Epidemiology and Public Health
Introduction: On February 16, 2021, a construction site in Harare recorded 26 COVID-19 cases during routine worker screening. Over five days, the positivity rate increased from 4.14 to 7.29%. Workplace outbreaks affect productivity.
Amanda Sarah Thakataka, Joseph Mberikunashe, Emmanuel Govha, Tsitsi Patience Juru, Notion Tafara Gombe, Mufuta Tshimanga   +5 more
doaj   +1 more source

Universal Generators for Primary Closures of Galois Fields [PDF]

, 2001
If \( \bar{F} \) is an algebraic closure of a Galois field F, then for each integer n ≥ 1 there is exactly one subfield E n of \( \bar{F} \) containing F and having degree n over F. For a prime number r, we consider the r-primary closure \( {\bar{F}_{r}}: = \bigcup {_{{m \geqslant 0}}{E_{{{r^{m}}}}}} \) over F and prove, under the assumption that r ≥ 7,
openaire   +1 more source

Effective field theories for topological insulators by functional bosonization

, 2013
Effective field theories that describes the dynamics of a conserved U(1) current in terms of "hydrodynamic" degrees of freedom of topological phases in condensed matter are discussed in general dimension $D=d+1$ using the functional bosonization ...
Chan, AtMa, Fradkin, Eduardo, Hughes, Taylor L., Ryu, Shinsei   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Characteristics of medicinal plants in protected area “Dabeto” village Novi izvor (Bulgaria)

Растениевъдни науки, 2019
The present study examines the medicinal plants in the protected area PA "Dabeto", Novi izvor village in the region of Plovdiv. The received data is based on a three-year research of the flora in the protected zone.
Stoyan Georgiev, Koycho Koev, Teodora Barakova, Nikolay Kochev   +3 more
doaj