Results 131 to 140 of about 6,237,714 (303)

Developing a digital phenotype to subdivide adult immunosuppressed COVID-19 outcomes within the English Primary Care Sentinel Network

Frontiers in Immunology
BackgroundAdults classified as immunosuppressed have been disproportionately affected by the COVID-19 pandemic. Compared to the immunocompetent, certain patients are at increased risk of suboptimal vaccine response and adverse health outcomes if infected.
Meredith Leston, Debasish Kar, Anna Forbes, Gavin Jamie, Rashmi Wimalaratna, Gunjan Jiwani, José M. Ordóñez-Mena, Daniel E. Stewart, Daniel E. Stewart, Heather Whitaker, Mark Joy, Lennard Y. W. Lee, F. D. Richard Hobbs, Simon de Lusignan   +13 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Estimating the crop coefficient of meadow ecosystems and its driving factors using machine learning on the Qinghai–Tibet Plateau

Journal of Hydrology: Regional Studies
Study region: Qinghai–Tibet Plateau (QTP), China Study focus: This study aims to improve crop coefficient (Kc) estimation for alpine meadows on the Qinghai–Tibet Plateau, where data scarcity and complex climate conditions make evapotranspiration (ET ...
Zhiming Xia, Bin Wang, Liping Guo, Xiaowei Guo   +3 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Measles Outbreak in Lambu Internally Displaced Persons´ Camp, Maiduguri, Borno State, Nigeria, 2017

Journal of Interventional Epidemiology and Public Health
Introduction: Measles, a highly infectious disease caused by the Measles virus, is endemic in Nigeria. Although children are vaccinated against measles at the age of nine months which has led to a significant reduction in morbidity and mortality ...
Taiwo Israel Olasoju, Mary Idowu Olasoju, Batula Bishara Daggash, Bio Belu Abaye, Chibuike Enumah, Salisu Isah1, Mohammed Tahiru Bolori, Oluwawemimo Oluseun Adebowale   +7 more
doaj   +1 more source

Secondary use of data recorded in primary care: insights from human computer interaction field studies [PDF]

, 2011
Introduction: Electronic health records from primary care, are now aggregated in a number of large datasets from primary care settings, containing both coded data and free-text. Secondary users can easily undertake analyses using coded data.
Axelrod, Lesley, Cassell, Jackie, Fitzpatrick, Geraldine Ann, Henwood, Flis, Nicholson, Amanda, Rait, Greta, Smith, Helen   +6 more
core   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source