Results 101 to 110 of about 1,558,129 (300)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Distributed Secondary Frequency Control through MTDC Transmission Systems [PDF]

, 2015
In this paper, we present distributed controllers for sharing primary and secondary frequency control reserves for asynchronous AC transmission systems, which are connected through a multi-terminal HVDC grid.
Dimarogonas, Dimos V,, Dimarogonas, Dimos V, Karl H. Johansson, Roger Wiget, Andreasson, Martin,, Martin Andreasson, Johansson, Karl H., Dimos V. Dimarogonas, Wiget, Roger,, Andreasson, Martin, Andersson, Göran, Andersson, Göran,, Wiget, Roger, Goran Andersson, Johansson, Karl H.,   +14 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Challenges on primary frequency control and potential solution from EVs in the future GB electricity system [PDF]

, 2016
System inertia reduction, driven by the integration of renewables, imposes significant challenges on the primary frequency control. Electrification of road transport not only reduces carbon emission by shifting from fossil fuel consumption to cleaner ...
Wu, J, Mu, Yunfei, Jia, H, Teng, F, Teng, Fei, Zeng, Pingliang, Strbac, Goran, Jia, Hongjie, Wu, Jianzhong, Strbac, G, Mu, Y, Zeng, P   +11 more
core   +2 more sources

A Novel Contingency-Aware Primary Frequency Control for Power Grids with High CIG-Penetration [PDF]

, 2023
IEEEThe ever-growing trend of Converter-Interfaced Generation (CIG) integration in electrical power grids has led to a tremendous concern about systems\u27 inertia, stability, and frequency regulation effectiveness. During contingencies, like the loss of
Jiang Y, Khamisov OO, Terzija V, Sayfutdinov T, Vorobev P, Ali M   +5 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An Extended SFR Model With High Penetration Wind Power Considering Operating Regions and Wind Speed Disturbance

IEEE Access, 2019
High-penetration wind power grid access requires wind turbine generators (WTGs) to provide frequency regulation, and an accurate system frequency response (SFR) model is required for frequency stability analysis.
Jianfeng Dai, Yi Tang, Qi Wang, Ping Jiang, Yuqiang Hou   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source