Results 161 to 170 of about 126,407 (290)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Primary Graft Dysfunction in Lung Transplantation: An Overview of the Molecular Mechanisms. [PDF]

Int J Mol Sci
Jennekens J, Braithwaite SA, Luijk B, van der Kaaij NP, Vrisekoop N, de Jager SCA, de Heer LM.   +6 more
europepmc   +1 more source

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

Primary graft dysfunction in donor after brain death vs normothermic regional perfusion heart transplants. [PDF]

JHLT Open
Vu Maffei M, Kozuch JM, Mariski M, Philbrick M, Topik A, Azar F, Cole J, Urey MA, Pretorius V, Kearns MJ, Hong KN.   +10 more
europepmc   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Respiratory Viruses at Time of Lung Transplant and the Relationship to Primary Graft Dysfunction. [PDF]

Transpl Infect Dis
van den Bosch L, Kaur K, Varughese R, Hirji A, Weatherald J, Weinkauf J, Lien D, Garcia OF, Alvarez CC, Doucette K, Kabbani D, Halloran K.   +11 more
europepmc   +1 more source

Tacrolimus in solid organ transplantation [PDF]

, 1996
Fung, JJ, Starzl, TE, Todo, S
core  

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Primary graft dysfunction in heart transplantation: How to recognize it, when to institute extracorporeal membrane oxygenation, and outcomesCentral Message

JTCVS Open, 2021
Travis D. Hull, MD, PhD, Jerome C. Crowley, MD, MPH, Mauricio A. Villavicencio, MD, MBA, David A. D'Alessandro, MD   +3 more
doaj   +1 more source

Optimization of pretransplant amiodarone therapy to prevent primary graft dysfunction following heart transplantation. [PDF]

JHLT Open
Kwon YIC, Keller M, Lai A, Ambrosio M, Patel J, Fox K, Tchoukina IF, Shah KB, Fitch Z, Chery J, Quader M, Nicolato P, Kasirajan V, Hashmi ZA.   +13 more
europepmc   +1 more source