Results 161 to 170 of about 10,665,939 (329)

Genetics in Primary Headache Disorders

, 2023
[No Abstract ...
Karataş, Hülya, Yemişçi, Müge, Taşkıran Sağ, Aslıhan   +2 more
core  

Toward a Behavioral Reserve Model in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Behavioral impairment is common in amyotrophic lateral sclerosis (ALS) and strongly affects autonomy, caregiver burden, and outcomes, yet predictors of vulnerability remain unclear. We investigated whether premorbid regulatory traits and socio‐educational exposures are associated with behavioral phenotypes in ALS within a behavioral reserve ...
Francesca Palumbo, Barbara Iazzolino, Cristina Moglia, Umberto Manera, Enrico Matteoni, Sara Cabras, Giorgio Pellegrino, Emilio Minerva, Vita Passidomo, Rosario Vasta, Gabriele Mora, Fabrizio D’Ovidio, Antonio Canosa, Andrea Calvo, Adriano Chiò   +14 more
wiley   +1 more source

Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor

, 2023
: Objective: The objective of this study was to aggregate data for the first genomewide association study meta-analysis of cluster headache, to identify genetic risk variants, and gain biological insights. Methods: A total of 4,777 cases (3,348 men and 1,
Lund, Nunu, Borte, Sigrid, Fourier, Carmen S., Riedel-Heller, Steffi, Jensen, Rigmor H., Bacchelli, Elena, Pirinen, Matti, Skogholt, Anne Heidi, Guerzoni, Simona, Chen, Shih-Pin, Pedersen, Ole E., Tronvik, Erling, Winsvold, Bendik, Heinze, Katja, Noordam, Raymond, K\ufc\ue7\ufckali, Fahri, Vandrovcova, Jana, Kubisch, Christian, Danno, Daisuke, Mehta, Dwij R., Vijfhuizen, Lisanne, van Dijk, Ko Willems, Wagner, Michael, Ferkingstad, Egil, Tripathi, Kumar Parijat, Ribases, Marta, Wang, Yen-Feng, Steinberg, Anna, Stefansson, Kari, Gallardo, Victor J., Sleegers, Kristel, Belin, Andrea C., Ramirez, Alfredo, Yip, Janice, O'Connor, Emer, Kristoffersen, Espen S., Kelderman, Tim, Terwindt, Gisela C., Zoli, Michele, Dardiotis, Efthimios, Trembath, Richard C., Vikelis, Michail, Happola, Paavo, Wilbrink, Leopoldine A., Paemeleire, Koen H., Magnusson, Sigurdur, de Boer, Irene, Hautakangas, Heidi, Waldenlind, Elisabet, Bjornsdottir, Gyda, Chalmer, Mona, Ramos-Quiroga, Josep A., Fann, Cathy Shen-Jang, Gabrielsen, Maiken E., Pani, Luca, Heinze, Axel, Ostrowski, Sisse S., Petersen, Anja H., Quinn, Olivia, Sveinsson, Olafur, Hansen, Thomas F., Fronczek, Rolf A., Scherer, Martin, Artigas, Maria S., Cainazzo, Maria Michela, Volk, Alexander, Cirkel, Anna, Southgate, Laura, Harder, Aster V. E. A., Thorgeirsson, Thorgeir E., Heilmann-Heimbach, Stefanie E., Guobjartsson, Daniel F., Ran, Caroline, Sivakumar, Prasanth, Thomas, Laurent F., Goebel, Hartmut A., Adebimpe, Joycee, Dalmasso, Maria Carolina, Callesen, Ida, Olofsgard, Felicia Jennysdotter, Lagrata, Susie, Goebel, Carl E., Zwart, John-Anker, Matharu, Manjit, Martinsen, Amy E., Rosendaal, Frits R., Houlden, Henry, Hsu, Chia-Lin, Sjostrand, Christina, Pozo-Rosich, Patricia, Stefansson, Hreinn, van den Maagdenberg, Arn M. J. M., Maestrini, Elena   +92 more
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Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Adverse event from drugs commonly employed in the headache attack treatment and prophylaxis: reuslts from a pharmacovigilance survey

, 2002
In view of the fact that the expected benefit of headache pharmacological treatment is not a definitive cure, the side effects of the drugs most employed in headache treament assume great importance in clinical ...
FERRARI, Anna, Bertolini A, Sternieri E., Cicero AFG   +3 more
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Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Accelerated Brain Atrophy in Epilepsy: A Prospective Population‐Based Study

Annals of Neurology, EarlyView.
Objective Previous longitudinal neuroimaging studies suggest that epilepsy is a progressive disorder. To date, these findings have relied largely on populations from tertiary centers, resulting in ascertainment bias, as severely affected individuals are more likely to be rescanned.
Marian Galovic, Rebecca S. N. Liu, Alex D. Everitt, Robert Terziev, Louis Lemieux, Matthias J. Koepp, John S. Duncan   +6 more
wiley   +1 more source

Perceptions, understandings and experiences of cluster headache patients in the north of England: a qualitative study

, 2015
Background: Very few qualitative studies on cluster headache have been conducted. As a result we have little in-depth understanding of the perceptions and experiences of cluster headache patients and the health professionals who treat them.
Ahmed, F., Goadsby, P. J., Quarshie, V., Paemeleire, K., Dikomitis, L.   +4 more
core  

Cortical Thickness and White Matter Surface Morphology in Tourette Syndrome: A Cohort Study

Annals of Neurology, EarlyView.
Objective To examine cortical thickness and white matter surface morphology in a large sample of individuals with Tourette syndrome (TS) and neurotypical controls across the lifespan, and to assess associations with symptom severity, comorbidities, and medication use.
Sahar Delavari, Adam C. Frank, Ravi Bansal, Flora M. Vaccarino, Robert A. King, Paul Lombroso, Lawrence Scahill, James F. Leckman, Bradley S. Peterson   +8 more
wiley   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source