Results 131 to 140 of about 123,736 (229)

Misperception of Visual Verticality in Patients with Primary Headache Disorders: A Systematic Review with Meta-Analysis. [PDF]

Brain Sci, 2020
Obrero-Gaitán E, Manrique-Navarro M, Lérida-Ortega MÁ, Rodríguez-Almagro D, Osuna-Pérez MC, Lomas-Vega R.   +5 more
europepmc   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Update on Neuromodulation for Migraine and Other Primary Headache Disorders: Recent Advances and New Indications. [PDF]

Curr Pain Headache Rep
Cocores AN, Smirnoff L, Greco G, Herrera R, Monteith TS.   +4 more
europepmc   +1 more source

Effect of Sleep Quality on Headache-Related Impact in Primary Headache Disorders. [PDF]

J Clin Neurol, 2020
Cho S, Lee MJ, Park HR, Kim S, Joo EY, Chung CS.   +5 more
europepmc   +1 more source

Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib

British Journal of Clinical Pharmacology, EarlyView.
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang, Yunlan Fang, Phillip Wang, Xiang Liu, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

Pituitary cyclase-activating polypeptide targeted treatments for the treatment of primary headache disorders. [PDF]

Ann Clin Transl Neurol
Karsan N, Edvinsson L, Vecsei L, Goadsby PJ.   +3 more
europepmc   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

The prevalence of primary headache disorders in Saudi Arabia: a cross-sectional population-based study. [PDF]

J Headache Pain, 2020
Al Jumah M, Al Khathaami AM, Kojan S, Hussain M, Thomas H, Steiner TJ.   +5 more
europepmc   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

The burdens attributable to primary headache disorders in children and adolescents in Iran: estimates from a schools-based study. [PDF]

J Headache Pain
Togha M, Rafiee P, Haghdoost F, Rafie S, Paknejad SMH, Amouian S, Şaşmaz T, Kale D, Uluduz D, Steiner TJ.   +9 more
europepmc   +1 more source