Results 141 to 150 of about 7,416,697 (314)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

External Validation of a Prediction Model for Falls in Older People Based on Electronic Health Records in Primary Care

, 2022
Noman Dormosh, Martijn W. Heymans, Nathalie van der Velde, Jacqueline G. Hugtenburg, Otto R Maarsingh, Pauline Slottje, Ameen Abu‐Hanna, Martijn C. Schut   +7 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Providing Preventive Oral Health Care to Infants and Young Children in Women, Infants, and Children (WIC), Early Head Start, and Primary Care Settings [PDF]

, 2013
This report focuses on seven oral health programs that provide preventive oral health care to young children (infants, toddlers, and children up to 5 years old) in Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), Early Head ...
D. Krol, K. Cheung, K. Cruz, L. Carver, M. Revels   +4 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A basic model for assessing primary health care electronic medical record data quality [PDF]

, 2019
Amanda Terry, Moira Stewart, Sonny Cejic, Jonathan Marshall, Simon de Lusignan, Bert M. Chesworth, Vijaya Chevendra, Heather Maddocks, Joshua Shadd, Fred Burge, Amardeep Thind   +10 more
openalex   +1 more source

Implementing Standard Antenatal Care Interventions: Health System Cost at Primary Health Facilities in Tanzania. [PDF]

, 2021
Amisa Tindamanyile Chamani, Amani Thomas Mori, Bjarne Robberstad   +2 more
openalex   +1 more source

Primary health care nurses caring for people with diabetes: An integrative review of the literature [PDF]

, 2010
The aim of this integrative literature review was to analyse and synthesize findings from primary empirical studies concerning how nurses in primary care, care for people with diabetes (PWD). Diabetes is a recognized health priority in United Kingdom
Cowley, Julie
core  

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

The primary health-care system in China

The Lancet, 2017
Xi Li, Jiapeng Lu, Shuang Hu, K. Cheng, J. Maeseneer, Q. Meng, Elias Mossialos, D. Xu, W. Yip, Hongzhao Zhang, H. Krumholz, Lixin Jiang, Shengshou Hu   +12 more
semanticscholar   +1 more source