Results 41 to 50 of about 2,092,566 (334)

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Trends in the epidemiology of depression and comorbidities from 2000 to 2019 in Belgium

BMC Primary Care, 2022
Background Depression is a common mental disorder in family practice with an impact on global health. The aim of this study is to provide insight in the trends of epidemiological measures as well as pharmacological treatments and comorbidities of ...
Roosje Walrave, Simon Gabriël Beerten, Pavlos Mamouris, Kristien Coteur, Marc Van Nuland, Gijs Van Pottelbergh, Lidia Casas, Bert Vaes   +7 more
doaj   +1 more source

Dissecting Medical Referral Mechanisms in Health Services: Role of Physician Professional Networks [PDF]

arXiv, 2023
Medical referrals between primary care physicians (PC) and specialist care (SC) physicians profoundly impact patient care regarding quality, satisfaction, and cost. This paper investigates the influence of professional networks among medical doctors on referring patients from PC to SC.
arxiv  

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Knowledge, attitude, and proficiency of healthcare providers in cardiopulmonary resuscitation in a public primary healthcare setting in Qatar

Frontiers in Cardiovascular Medicine, 2023
IntroductionEarly and effective cardiopulmonary resuscitation (CPR) increases both survival rate and post–cardiac arrest quality of life. This study aims to assess the current knowledge and ability of physicians and nurses in health centers (HCs ...
Shajitha Thekke Veettil, Mohamed Shaheen Anodiyil, Hanan Khudadad, Mohamed Ali Kalathingal, Abdul Hakeem Hamza, Femina Purakaloth Ummer, Ahmed Sameer Alnuaimi   +6 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Plantar heel pain in middle-aged and older adults: population prevalence, associations with health status and lifestyle factors, and frequency of healthcare use

BMC Musculoskeletal Disorders, 2019
Background The objectives of this study were to estimate the population prevalence and distribution of plantar heel pain in mid-to-older age groups, examine associations with selected health status and lifestyle factors, and report the frequency of ...
Martin J. Thomas, Rebecca Whittle, Hylton B. Menz, Trishna Rathod-Mistry, Michelle Marshall, Edward Roddy   +5 more
doaj   +1 more source

The Newcomer Health Clinic in Nova Scotia: A Beacon Clinic to Support the Health Needs of the Refugee Population [PDF]

International Journal of Health Policy and Management, 2018
Refugees tend to have greater vulnerability compared to the general population reporting greater need for physical, emotional, or dental problems compared to the general population.
Graeme Kohler, Timothy Holland, Ashley Sharpe, Mandi Irwin, Tara Sampalli, Kolten MacDonell, Natalie Kidd, Lynn Edwards, Rick Gibson, Amy Legate, Ruth Ampi Kanakam   +10 more
doaj   +1 more source

Robotics Technology in Mental Health Care [PDF]

Artificial Intelligence in Behavioral Health and Mental Health Care (2015) 185-203;, 2015
This chapter discusses the existing and future use of robotics and intelligent sensing technology in mental health care. While the use of this technology is nascent in mental health care, it represents a potentially useful tool in the practitioner's toolbox. The goal of this chapter is to provide a brief overview of the field, discuss the recent use of
arxiv   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source