Results 91 to 100 of about 5,001,259 (276)

Primary Hyperparathyroidism With Brown Tumor—A Case Mistaken as Non‐Ossifying Fibroma Resolved by Biochemical and Radiological Correlation

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Primary hyperparathyroidism (PHPT) is uncommon in the pediatric population and rarely presents with overt skeletal complications such as brown tumors. This case study describes a 16‐year‐old female who initially presented with abdominal pain and was subsequently found to have severe hypercalcemia (serum calcium 16.4 mg/dL) and markedly ...
Dosti Regmi, Uma Bhatta, Madhur Bhattarai, Saurav Jha, Akriti Baral   +4 more
wiley   +1 more source

Prevalence of Metabolic Syndrome in Primary Hyperparathyroidism

Haseki Tıp Bülteni, 2017
Aim: In this study, we aimed to evaluate the prevalence of metabolic syndrome (MetS), metabolic abnormalities and independent predictors of MetS in primary hyperparathyroidism and to contribute to long-term follow-up and management of these patients ...
Gökçen Tuğba Çevik, Sibel Güldiken, Neslihan Soysal Atile, Hüseyin Çelik, Mehmet Çelik, Semra Aytürk, Necdet Süt, Ayşe Armağan Tuğrul   +7 more
doaj   +1 more source

Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Female‐specific bone loss in Alzheimer's disease mouse models: There is a significant alteration of bone phenotype during Alzheimer's disease. Using integrated imaging and biological assays, we observed changes in the bone microarchitecture, composition, and function in PSEN K1 and PSEN1/hAPP Tg+ mice, predominantly in the females. ABSTRACT Accelerated
Vidyani Suryadevara, Connor J. Krehbial, Anuradha K. Valiya, Melinda Vang, Julian Balanta‐Melo, Pierre P. Eleniste, Sumana Posritong, Jung Min Hong, Katie Chester, Gabriel M. Pagnotti, Teresita Bellido, Monte S. Willis, Angela Bruzzaniti   +12 more
wiley   +1 more source

A Lost Opportunity: Early Nephrolithiasis as a Missed Indicator of Primary Hyperparathyroidism Over Eight Years

Clinical Case Reports
Primary hyperparathyroidism may present with a diagnostic challenge due to its nonspecific initial symptoms, often delaying diagnosis. Nephrolithiasis, a common presentation, is often treated in isolation without consideration of an underlying ...
Prince Yaw Boahene, Solomon Gyabaah, Seth Kyei‐Fram, Paulinus Domeh, Afia Serwaa Bonsu, Bernard C. Nkum   +5 more
doaj   +1 more source

Bradycardia secondary to primary hyperparathyroidism

Journal of International Medical Research, 2019
Clinical doctors rarely associate hyperparathyroidism with significant bradyarrhythmia. We report a rare case of a patient initially misdiagnosed with primary sick sinus syndrome, which was eventually shown to be secondary to primary hyperparathyroidism.
Fei Liu, Zechang Xin, Yunlong Xia, Xiaomeng Yin   +3 more
doaj   +1 more source

Avascular Necrosis and Minimal Trauma Fractures in Telomere Biology Disorders

Clinical Genetics, Volume 109, Issue 2, Page 286-293, February 2026.
Avascular Necrosis (AVN) and Minimal Trauma Fractures (MTF) cause significant morbidity in people with Telomere Biology Disorders (TBDs). They occur more frequently in young patients and in those with autosomal recessive (AR) or X‐linked recessive (XLR) than in autosomal dominant (AD) genotypes.
Arman M. Niknafs, Neelam Giri, Marena R. Niewisch, Sharon A. Savage   +3 more
wiley   +1 more source

Lysophosphatidic Acid Synergizes With 1,25‐Dihydroxyvitamin D to Promote Fibroblast Growth Factor‐23 Synthesis via MAPK Signaling and Induction of the IL12A Gene

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Ay et al. investigated the cellular mechanisms behind the role of lysophosphatidic acid (LPA) in FGF23 production. They revealed that LPA cooperates with 1,25‐dihydroxyvitamin D (1,25D), that is, the bioactive form of vitamin D known to stimulate FGF23 synthesis. This synergy entails MAPK signaling and the induction of the gene encoding the interleukin‐
Birol Ay, Sajin Marcus Cyr, Yorihiro Iwasaki, Elizabeth Hill, Eugene P. Rhee, Nevil J. Singh, Petra Simic, Murat Bastepe   +7 more
wiley   +1 more source

Parathyroidectomy Resolves Tooth Discoloration: A New Presenting Sign of Hyperparathyroidism?

Case Reports in Dentistry, 2020
Introduction. We report the resolution of tooth discoloration following parathyroidectomy in an otherwise asymptomatic woman with primary hyperparathyroidism-associated hypercalcemia. Case Report.
Estella Musacchio, Andrea Piotto, Pierluigi Binotto, Antonio Toniato, Leonardo Sartori   +4 more
doaj   +1 more source

SAT181 Clinical Profile And Treatment Outcomes Of Patients With Sporadic And Multiple Endocrine Neoplasia Syndrome-related Primary Hyperparathyroidism

, 2023
Uthara Elsa Mathew, Viveka P. Jyotsna, Ashish S Upadhyay, Alpesh Goyal, Devasenathipathy Kandaswamy, Chandra S. Bal, Arundhati Sharma, Chitresh Kumar Sharma, Shipra Aggarwal, Nikhil Tandon   +9 more
openalex   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, Volume 13, Issue 4, 19 January 2026.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source