Results 1 to 10 of about 1,032 (114)

Primary Hypertrophic Osteoarthropathy With Myelofibrosis. [PDF]

Cureus, 2022
Primary hypertrophic osteoarthropathy (PHO) is a rare autosomal recessive inherited multi-system disorder characterized by a triad of pachydermia, periostosis, and clubbing. PHO was revealed to be caused by the HPGD gene producing 15-prostaglandin dehydrogenase and the SLCO2A1 gene expressing one kind of prostaglandin transporter.
Yousaf M, Khan R, Akram Z, Chaudhry QU, Iftikhar R.   +4 more
europepmc   +2 more sources

Incomplete primary hypertrophic osteoarthropathy. [PDF]

BMJ Case Rep, 2020
A 63-year-old man presented with chronic multiple joint pain and swelling. The symptoms had started in adolescence, progressed for about 10–15 years, and then became constant. There was no associated morning stiffness. Symptoms suggesting any chest or abdominal disease were absent.
Prasad A, Shahi P, Sehgal A, Bhagirathi Mallikarjunaswamy M.   +3 more
europepmc   +5 more sources

Primary hypertrophic osteoarthropathy: genetics, clinical features and management. [PDF]

Front Endocrinol (Lausanne), 2023
Primary hypertrophic osteoarthropathy (PHO) is a genetic disorder mainly characterized by clubbing fingers, pachydermia and periostosis. Mutations in the HPGD or SLCO2A1 gene lead to impaired prostaglandin E2 (PGE2) degradation, thus elevating PGE2 levels.
Lu Q, Xu Y, Zhang Z, Li S, Zhang Z.
europepmc   +4 more sources

Pachydermoperiostosis or primary hypertrophic osteoarthropathy: A rare clinicoradiologic case.

Indian J Radiol Imaging, 2009
AbstractPachydermoperiostosis (PDP) or primary hypertrophic osteoarthropathy is a rare syndrome with diverse radiological and clinical features. Though the diagnosis can be made on the basis of the classic clinical and radiological features, it is often missed due to variable presentations.
Rastogi R, Suma GN, Prakash R, Rastogi UC, Bhargava S, Rastogi V.   +5 more
europepmc   +4 more sources

Collagen‐Based Hydrogels for Cartilage Regeneration

Orthopaedic Surgery, Volume 15, Issue 12, Page 3026-3045, December 2023., 2023
This review provided an overview of the progress made in research on collagen hydrogels with chondrocytes or stem cells, comprehensively covered the research progress and clinical applications of collagen‐based hydrogels that integrated inorganic or organic materials. Cartilage regeneration remains difficult due to a lack of blood vessels.
Lihui Sun, Yan Xu, Yu Han, Jing Cui, Zheng Jing, Dongbo Li, Jianguo Liu, Chunsheng Xiao, Dongsong Li, Bo Cai   +9 more
wiley   +1 more source

Biomechanical Impact of Phosphate Wasting on Articular Cartilage Using the Murine Hyp Model of X‐linked hypophosphatemia

JBMR Plus, Volume 7, Issue 10, October 2023., 2023
ABSTRACT Degenerative osteoarthritis (OA) is recognized as an early‐onset comorbidity of X‐linked hypophosphatemia (XLH), contributing to pain and stiffness and limiting range of motion and activities of daily living. Here, we extend prior findings describing biochemical and cellular changes of articular cartilage (AC) in the phosphate‐wasting ...
Carolyn M Macica, Steven M Tommasini
wiley   +1 more source

Primary Hypertrophic Osteoarthropathy with Gastric Hypertrophy [PDF]

The Journal of Rheumatology, 2011
Primary hypertrophic osteoarthropathy (HOA) is a rare congenital disease that is not well recognized. Gastric hypertrophy will be infrequently involved; only 3 case reports describe this scarce manifestation in the English-language literature1,2,3. A 19-year-old Chinese male presented with a 4-year history of thickened skin and joint pain and swelling.
Sun, Xue-Feng, Wu, Qing-Jun, Bi, Ya-Lan, Hou, Yong, Li, Meng-Tao, Zhang, Wen, Zhang, Xuan, Zhao, Yan, Zeng, Xiao-Feng, Zhang, Feng-Chun, Tang, Fu-Lin   +10 more
openaire   +4 more sources

Complete form of pachydermoperiostosis with good initial response to etoricoxib: A case report

Clinical Case Reports, Volume 11, Issue 6, June 2023., 2023
X‐ray of hand showing cortical thickening and periosteal reaction in distal radius ulna and phalynges of hand of a patient with pachydermoperiostosis. Key Clinical Message Pachydermoperiostosis is a rare genetic disorder that closely resembles acromegaly. Diagnosis is usually based on distinct clinical and radiological features. Oral etoricoxib therapy
Abinash Baniya, Ayam Bhattarai, Bibek Devkota, Saurav Khatiwada, Pramod Kumar Kafle, Achyut Krishna Phuyal, Manoj Shahi   +6 more
wiley   +1 more source

Nosology of genetic skeletal disorders: 2023 revision

American Journal of Medical Genetics Part A, Volume 191, Issue 5, Page 1164-1209, May 2023., 2023
Abstract The “Nosology of genetic skeletal disorders” has undergone its 11th revision and now contains 771 entries associated with 552 genes reflecting advances in molecular delineation of new disorders thanks to advances in DNA sequencing technology.
Sheila Unger, Carlos R. Ferreira, Geert R. Mortier, Houda Ali, Débora R. Bertola, Alistair Calder, Daniel H. Cohn, Valerie Cormier‐Daire, Katta M. Girisha, Christine Hall, Deborah Krakow, Outi Makitie, Stefan Mundlos, Gen Nishimura, Stephen P. Robertson, Ravi Savarirayan, David Sillence, Marleen Simon, V. Reid Sutton, Matthew L. Warman, Andrea Superti‐Furga   +20 more
wiley   +1 more source

A case report of an extremely rare association of ankylosing spondylitis with pachydermoperiostosis

Clinical Case Reports, Volume 11, Issue 5, May 2023., 2023
Key Clinical Message We describe a case of a young man with features of pachydermoperiostosis and spondyloarthropathy. By describing this rarity, we aim to help build a database for future studies and construct a management plan that rheumatologists and clinicians can use.
Faiq I. Gorial, Nabaa Ihsan Awadh, Maryam A. Hamzah   +2 more
wiley   +1 more source