Results 11 to 20 of about 2,284 (202)

Distinct features of three clinical subtypes in 533 patients with primary hypertrophic osteoarthropathy [PDF]

Orphanet Journal of Rare Diseases
Background Primary hypertrophic osteoarthropathy (PHO) is a rare genetic disorder classified into clinical subtypes and genetic subtypes. Previous clinical studies have primarily focused on case reports and family analyses, largely characterizing the ...
Xilei Cai, Xiujuan Yang, Pengyue Zhang, Ziyue Dou, Zilian Chen, Chongzhi Zhu, Weiwei Xu, Xinchen Wang, Xiaodan Hong, Zhenhua Zhang   +9 more
doaj   +2 more sources

Primary hypertrophic osteoarthropathy related gastrointestinal complication has distinctive clinical and pathological characteristics: two cases report and review of the literature [PDF]

Orphanet Journal of Rare Diseases, 2019
Background Primary hypertrophic osteoarthropathy (PHO) is a rare disease related to HPGD and SLCO2A1 gene mutation. Gastrointestinal involvement of PHO is even rarer with unknown pathogenesis. Clinical features of GI complication in PHO mimics other auto-
Qiang Wang, Ying-he Li, Guo-le Lin, Yue Li, Wei-xun Zhou, Jia-ming Qian, Wei-bo Xia, Dong Wu   +7 more
doaj   +2 more sources

Safety and efficacy of cyclooxygenase-2 inhibition for treatment of primary hypertrophic osteoarthropathy: A single-arm intervention trial [PDF]

Journal of Orthopaedic Translation, 2019
Background: Primary hypertrophic osteoarthropathy (PHO) is a rare disease involving joint, bone and skin. Two underlying genes responsible for this disease—hydroxyprostaglandin dehydrogenase (HPGD) and solute carrier organic anion transporter family ...
Lu Yuan, Ruo-xi Liao, Yuan-yuan Lin, Yan Jiang, Ou Wang, Mei Li, Xiao-ping Xing, Qian-qian Pang, Evelyn Hsieh, Wei-bo Xia   +9 more
doaj   +2 more sources

Two cases of primary hypertrophic osteoarthropathy caused by HPGD variants: a case report and literature review [PDF]

BMC Pediatrics
Background Primary hypertrophic osteoarthropathy (PHO) is a rare genetic disorder primarily characterized by digital clubbing, pachydermia, and periostitis. The rarity of this disease often leads to misdiagnosis or delayed diagnosis.
Jun Li, Shilei Jia, Jianqun Guo, Wenhui Xie, Yijiao Ma, Xiaojie Gao, Meihao Gao   +6 more
doaj   +2 more sources

Primary Hypertrophic Osteoarthropathy: A Case Series [PDF]

Journal of Marine Medical Society
Abstract Primary hypertrophic osteoarthropathy (PHOA) is a rare genetic disorder defined by digital clubbing, periostosis of long bones, and musculoskeletal pain. Differentiating it from secondary hypertrophic osteoarthropathy, which is associated with pulmonary or cardiac disease, is essential to avoid misdiagnosis and inappropriate ...
Ramakant Singh, Kunal Kishore, J. Sankar, Avneet Kumar Gupta, Abhishek Kumar, Dev Prakash Sharma, Puran Padwal   +6 more
core   +4 more sources

SLCO2A1 gene is the causal gene for both primary hypertrophic osteoarthropathy and hereditary chronic enteropathy [PDF]

Journal of Orthopaedic Translation, 2021
Junji Umeno, Takayuki Matsumoto, Yuta Fuyuno, Motohiro Esaki, Takehiro Torisu   +4 more
doaj   +2 more sources

Primary Hypertrophic Osteoarthropathy: A Case Report

Case Reports in Clinical Practice, 2018
The primary hypertrophic osteoarthropathy (PHOA or pachydermoperiostosis) is a rare (5% of total HOA) hereditary disease. One study described that the prevalence of PHOA is 0.16%.
Shima Asadi-Komeleh, Abdolrahman Rostamian, Fatemeh Shahbazi, Shafieh Movassagi, Parviz Soofivand   +4 more
doaj   +1 more source

Hypertrophic Osteopathy Associated With Intrathoracic Masses in 5 Dogs and Review of the Literature. [PDF]

Vet Med Int
This study describes the clinical and radiographical findings of hypertrophic osteopathy in 5 female mature adult dogs with pulmonary and mediastinal masses. Besides, the literature review from the past to today provides information about the disease.
Cetinkaya MA, Cagatay S, Pilli M, Curukoglu A, Seyrek Intas D.   +4 more
europepmc   +2 more sources

Primary hypertrophic osteoarthropathy

Journal of Biomedical Graphics and Computing, 2011
A rare case of 25 years male who had intermittent swelling over the ankles as well as knees, for the past 7 years is presented here. This case report not only enables diagnosing primary hypertrophic arthropathy, by systematically excluding other differentials but also brings out essential differences between primary and secondary forms of this entity.
Francieli de Sousa, Rabelo, Ana Cristina V, Oliveira, Clarissa de C, Ferreira, Jamille N, Carneiro, Luciana A, Almeida, Regina A F, Von Kirchenheim, Cezar Kozak, Simann   +6 more
  +7 more sources

Complete form of pachydermoperiostosis, [PDF]

Anais Brasileiros de Dermatologia, 2020
Pachydermoperiostosis (PDP) or primary hypertrophic osteoarthropathy (PHO) is a rare hereditary disease characterized by digital clubbing, pachydermia, and periostosis. Its pathogenesis is uncertain and the diagnosis is based on clinical and radiological
Mônica Larissa Padilha Honório, Guilherme Holanda Bezerra, Vivianne Lira da Câmara Costa   +2 more
doaj   +1 more source