Results 251 to 260 of about 220,119 (313)

ADAR1 mRNA quantification for predicting HSIL in persons with HIV and abnormal anal cytology

International Journal of Cancer, EarlyView.
What's New? This study introduces ADAR1 mRNA quantification as a promising biomarker for improving high‐grade squamous intraepithelial lesion (HSIL) prediction in HIV‐positive individuals with abnormal anal cytology. With 92% specificity, it reduces unnecessary high‐resolution anoscopies (HRA) by 77%, offering a more efficient and targeted screening ...
Melissa Bello‐Perez, Paula Mascarell, Marta Fernández‐González, Jose Alberto García, Ana Gutiérrez‐Ortiz de la Tabla, Christian Ledesma, Alba De la Rica, Antonio Galiana, Leo López, Maria Dolores Ocete, Carme Salvador, Concepción Gimeno, Javier García‐Abellán, Sergio Padilla, Félix Gutiérrez, Mar Masiá   +15 more
wiley   +1 more source

Long-Term Safety of Facilitated Subcutaneous Immunoglobulin 10% Treatment in US Clinical Practice in Patients with Primary Immunodeficiency Diseases: Results from a Post-Authorization Safety Study. [PDF]

J Clin Immunol
Rubinstein A, Mabudian M, McNeil D, Patel NC, Wasserman RL, Gupta S, Carrasco P, Chen J, Garcia E, Nagy A, Yel L.   +10 more
europepmc   +1 more source

Impact of Treatment with Ustekinumab in Severe Infections in a Patient with Uncontrolled Psoriasis and Late-Onset Combined Primary Immunodeficiency: Case Report

, 2023
Prestes-Carneiro LE, Morgado de Abreu MAM, Roncada EVM, Muchon DG, Caliani FM, Vasconcelos DM.   +5 more
europepmc   +1 more source

Evaluation of endometriosis patients' expectations of a therapeutic patient education program and comparison with practitioners' perception

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Endometriosis significantly affects patients' quality of life, yet its management remains challenging due to diagnostic delays and symptom complexity. Therapeutic patient education (TPE) is effective in chronic disease management, but guidelines are lacking for its application in endometriosis care.
Emma Viteau, Marianne Roy, Jérôme Delotte, Pierre‐Alexis Gauci   +3 more
wiley   +1 more source

Saliva MicroAge: A salivary microbiome based machine learning model for noninvasive aging assessment and health state prediction

iMetaOmics, EarlyView.
Saliva MicroAge is a machine learning‐based model designed to estimate biological age and assess health status using globally sourced salivary microbiome data. Trained on 4532 healthy samples, the model achieves high accuracy in predicting chronological age and captures health‐related deviations (MicroAgeGap) in various diseases.
Tiansong Xu, Yuting Niu, Chenyu Deng, Yoo Cheung, Yuman Li, Zhewen Hu, Shiyu Sun, Yiming Chen, Fan He, Gai Yang, Feng Chen, Chenggang Duan, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

The Inborn Errors of Immunity-Virtual Consultation System Platform in Service for the Italian Primary Immunodeficiency Network: Results from the Validation Phase. [PDF]

J Clin Immunol
Coppola E, Sgrulletti M, Cortesi M, Romano R, Cirillo E, Giardino G, Dotta L, Cancrini C, Bruzzese D, Badolato R, Moschese V, Pignata C, IEI-VCS Task Force.   +12 more
europepmc   +1 more source

Gut microbiota and tuberculosis

iMeta, EarlyView.
This review explores the intricate relationship between gut microbiota (GM) and tuberculosis (TB). The figure illustrates the bidirectional effects between GM dynamics and TB progression, as well as the interactions between the GM and antituberculosis drugs.
Yanhua Liu, Ling Yang, Maryam Meskini, Anjana Goel, Monique Opperman, Sagar Singh Shyamal, Ajay Manaithiya, Meng Xiao, Ruizi Ni, Yajing An, Mingming Zhang, Yuan Tian, Shuang Zhou, Zhaoyang Ye, Li Zhuang, Linsheng Li, Istuti Saraswat, Ankita Kar, Syed Luqman Ali, Shakir Ullah, Syed Yasir Ali, Shradha Kaushik, Tianmu Tian, Mingyang Jiao, Shujun Wang, Giulia Ghisleni, Alice Armanni, Sara Fumagalli, WenYu Wang, Chao Cao, Maria Carpena, Miguel A. Prieto, Antonia Bruno, Chanyuan Jin, Hanqing Hu, Yuhang Zhang, Ilse du Preez, Ashok Aspatwar, Lingxia Zhang, Wenping Gong   +39 more
wiley   +1 more source

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

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Primary Immunodeficiency and Thrombocytopenia

International Reviews of Immunology, 2021
Primary immunodeficiency (PID) or Inborn errors of immunity (IEI) refers to a heterogeneous group of disorders characterized by immune system impairment. Although patients with IEI manifest highly variable symptoms, the most common clinical manifestations are recurrent infections, autoimmunity and malignancies.
Maryam Mohtashami, Hassan Abolhassani, Hassan Abolhassani, Reza Yazdani, Asghar Aghamohammadi, Azadehsadat Razavi, Azadehsadat Razavi   +6 more
openaire   +3 more sources