Results 261 to 270 of about 220,119 (313)
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The Primary Immunodeficiencies
New England Journal of Medicine, 1984The primary immunodeficiency disorders reflect abnormalities in the development and maturation of cells of the immune system. These defects result in an increased susceptibility to infection; recurrent pyogenic infections occur with defects of humoral immunity, and opportunistic infections with defects of cell-mediated immunity.
Ralph J. Wedgwood +2 more
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Journal of Allergy and Clinical Immunology, 2010
In the last years, advances in molecular genetics and immunology have resulted in the identification of a growing number of genes causing primary immunodeficiencies (PIDs) in human subjects and a better understanding of the pathophysiology of these disorders.
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In the last years, advances in molecular genetics and immunology have resulted in the identification of a growing number of genes causing primary immunodeficiencies (PIDs) in human subjects and a better understanding of the pathophysiology of these disorders.
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Primary Immunodeficiency and Rhinosinusitis
Immunology and Allergy Clinics of North America, 2020Refractory rhinosinusitis can be related to comorbid medical conditions, including primary immunodeficiency. Given the prevalence of immunodeficiency, clinicians should have a low threshold to consider these diagnoses. This article reviews primary immunodeficiencies contributing to chronic rhinosinusitis, including a proposed diagnostic work-up and the
Camille Huwyler +2 more
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Cytomegalovirus in primary immunodeficiency
Current Opinion in Infectious Diseases, 2021Purpose of review Cytomegalovirus (CMV) infection and disease are well described in the setting of secondary immunodeficiency. Less is known about CMV in the context of primary immunodeficiencies (PIDs), where inborn errors in one or more arms of the immune system result in variable degrees of CMV susceptibility.
Charlotte Slade +6 more
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Primary Immunodeficiency and the Gut
Gastroenterology Clinics of North America, 2019This article presents the most common gastrointestinal, hepatic, and pancreatic manifestations of the primary immunodeficiency diseases, including the appropriate laboratory testing, endoscopic evaluation, and recommendations for further management.
David Schwimmer, Sarah C. Glover
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Classification of Primary Immunodeficiencies
New England Journal of Medicine, 1973Primary specific immunodeficiency results from failure to manifest an efficient humoral or cellular immune response.
Henry G. Kunkel +9 more
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Primary Immunodeficiency Disorders
Immunology and Allergy Clinics of North America, 2015We are very pleased to be presenting this issue on Primary Immunodeficiency Disorders (PIDD). PIDD is an essential clinical topic for Allergy/Immunology practitioners as well as primary care providers. Given the delay in diagnosis of over ten years in most patients, it is incumbent on us to have a better understanding of these disorders and to get the ...
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Primary immunodeficiency registries
Current Opinion in Allergy & Clinical Immunology, 2007Research in the field of rare diseases such as primary immunodeficiencies can be significantly improved with sufficient patient numbers. Patient registries can help provide the basis for this by collecting data over a longer period of time and by connecting centres nationally or even internationally. The present article reviews recent publications both
Knerr, Viviane, Grimbacher, Bodo
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Gene Therapy for Primary Immunodeficiencies [PDF]
Hematology/Oncology Clinics of North America, 2010 Gene therapy has effectively entered Medicine via the field of primary immunodeficiencies (PID). Because hematopoietic stem cells are accessible and because it was understood that genetic correction of lymphocyte progenitor cells carrying a genetic defect impairing differentiation, could result in the production of long‐lived T lymphocytes, it was ...
Alain Fischer +3 more
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Approach to primary immunodeficiency
Allergy and Asthma Proceedings, 2019Primary immunodeficiency diseases are inherited defects of the innate or adaptive arms of the immune system that lead to an increase in the incidence, frequency, or severity of infections and/or immune dysregulation. There may be defects in the adaptive arm of the immune system, including combined immunodeficiencies and antibody deficiency syndromes ...
Ashley L Devonshire, Melanie M. Makhija
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