Results 1 to 10 of about 4,835,172 (209)

Recent advances in therapies for primary myelofibrosis. [PDF]

Fac Rev, 2023
Primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET) form the classical BCR-ABL1-negative myeloproliferative neoplasms (MPNs) that are driven by a constitutive activation of JAK2 signaling.
Vainchenker W, Yahmi N, Havelange V, Marty C, Plo I, Constantinescu SN.   +5 more
europepmc   +5 more sources

Focus on Osteosclerotic Progression in Primary Myelofibrosis [PDF]

Biomolecules, 2021
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by hematopoietic stem-cell-derived clonal proliferation, leading to bone marrow (BM) fibrosis.
M. Spampinato, C. Giallongo, A. Romano, L. Longhitano, E. La Spina, R. Avola, G. Scandura, I. Dulcamare, V. Bramanti, M. Di Rosa, N. Vicario, R. Parenti, G. Li Volti, D. Tibullo, G. Palumbo   +14 more
semanticscholar   +5 more sources

Primary myelofibrosis L.

Онкогематология, 2014
Literature data of idiopathic myelofibrosis are presented: classification, diagnostic criteria, morphological and molecular features. Particular attention is given to therapy of various clinical forms of primary myelofibrosis.
L. M. Meshcheryakova, O. V. Porotkova, L. G. Kovaleva, L. Yu. Kolosova, S. N. Bychkova   +4 more
doaj   +4 more sources

Triple immunostaining demonstrates the possible existence of segregated-nucleus-containing atypical monocytes in human primary myelofibrosis bone marrow: a case report [PDF]

Journal of Medical Case Reports
Background Segregated-nucleus-containing atypical monocytes have recently been identified in mice. Segregated-nucleus-containing atypical monocytes are thought to originate from the bone marrow and induce fibrosis in the drug-injured lung.
Shunsuke Homma, Toshie Ogasawara, Michie Suga, Yoshiyasu Nakamura, Katsuya Takenaka, Shoko Marshall, Kiyotaka Kawauchi, Naoki Mori, Hajime Kuroda, Naoya Nakamura, Yohei Miyagi, Atsuko Masunaga   +11 more
doaj   +2 more sources

From primary myelofibrosis to chronic myeloid leukemia, BCR::ABL1+ B‐Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolution [PDF]

eJHaem
The simultaneous detection of BCR::ABL1 and JAK2 V617F was rarely reported and their clonal relationship and dynamic clonal shift were not characterized. Here, we described a unique case with the initial presentation as JAK2 V617F+ primary myelofibrosis,
Devin Wang, Wataru Kamata, Fengxi Ye, M. James You   +3 more
doaj   +2 more sources

Targeted deep sequencing in primary myelofibrosis. [PDF]

Blood Advances, 2016
A myeloid neoplasm-relevant 27-gene panel was used for next-generation sequencing of bone marrow or whole blood DNA in 182 patients with primary myelofibrosis (PMF).
A. Tefferi, T. Lasho, C. Finke, Y. Elala, C. Hanson, R. Ketterling, N. Gangat, A. Pardanani   +7 more
semanticscholar   +5 more sources

Primary myelofibrosis: spectrum of imaging features and disease-related complications

Insights into Imaging, 2019
Primary myelofibrosis is a chronic clonal stem cell disorder that results in a build-up of marrow fibrosis and dysfunction, hypermetabolic states, and myeloid metaplasia.
Sheng Fei Oon, Dalveer Singh, Teng Han Tan, Allan Lee, Geertje Noe, Kate Burbury, Joseph Paiva   +6 more
doaj   +2 more sources

Primary myelofibrosis: current therapeutic options

Revista Brasileira de Hematologia e Hemoterapia, 2016
Primary myelofibrosis is a Philadelphia-negative myeloproliferative neoplasm characterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure.
Paula de Melo Campos
doaj   +5 more sources

Primary myelofibrosis: 2023 update on diagnosis, risk‐stratification, and management

American journal of hematology/oncology, 2023
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell‐derived clonal myeloproliferation that is often but not always accompanied by JAK2, CALR, or MPL mutations; additional features include bone marrow reticulin ...
A. Tefferi
semanticscholar   +1 more source

Higher estimated plasma volume status is associated with increased thrombotic risk and impaired survival in patients with primary myelofibrosis

Biochemia Medica, 2023
Introduction Blood plasma represents a large reservoir of cytokines and other mediators of inflammation. Higher estimated plasma volume status (ePVS) has been shown to correlate with increased thrombotic risk in polycythemia vera patients, but its ...
M. Lucijanić, I. Krečak, E. Sorić, A. Sabljić, D. Galušić, H. Holik, V. Periša, Martina Morić Perić, I. Zekanović, R. Kušec   +9 more
semanticscholar   +1 more source