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Primary myelofibrosis

Haematology, 2021
Primary myelofibrosis (PMF) is a Philadelphia negative myeloproliferative neoplasm characterized by bone marrow fibrosis, splenomegaly, anemia, constitutional symptoms, and extramedullary hematopoiesis. As a clonal hematopoietic stem cell disorder, it is
Nick Tarasov
semanticscholar   +3 more sources

Cytogenetics, JAK2 and MPL mutations in polycythemia vera, primary myelofibrosis and essential thrombocythemia [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: The detection of molecular and cytogenetic alterations is important for the diagnosis, prognosis and classification of myeloproliferative neoplasms. OBJECTIVE: The aim of this study was to detect the following mutations: JAK2 V617F, JAK2 exon
Leonardo Caires dos Santos, Juliana Corrêa da Costa Ribeiro, Neusa Pereira Silva, Janete Cerutti, Maria Regina Regis da Silva, Maria de Lourdes Lopes Ferrari Chauffaille   +5 more
doaj   +4 more sources

Primary Myelofibrosis [PDF]

Oxford Textbook of Medicine, 2020
Abstract Myelofibrosis is a reactive process common to many malignant and benign disorders. Primary myelofibrosis is a chronic myeloproliferative neoplasm arising in a pluripotent haematopoietic stem cell. It results in abnormalities in red cell, granulocyte, and platelet production in association with marrow fibrosis and extramedullary ...
Carmelo J. Blanquicett, Andrew Kuykendall   +1 more
semanticscholar   +6 more sources

miR-494-3p overexpression promotes megakaryocytopoiesis in primary myelofibrosis hematopoietic stem/progenitor cells by targeting SOCS6 [PDF]

, 2017
Primary myelofibrosis (PMF) is a chronic Philadelphia-negative myeloproliferative neoplasm characterized by hematopoietic stem cell-derived clonal myeloproliferation, involving especially the megakaryocyte lineage.
Barosi, Giovanni, Bianchi, Elisa, Guglielmelli, Paola, Manfredini, Rossella, Norfo, Ruggiero, Pennucci, Valentina, Prudente, Zelia, Rontauroli, Sebastiano, Rossi, Chiara, Rosti, Vittorio, Ruberti, Samantha, Salati, Simona, Tagliafico, Enrico, Vannucchi, Alessandro, Zini, Roberta   +14 more
core   +3 more sources

A case of mistaken identity: When lupus masquerades as primary myelofibrosis [PDF]

SAGE Open Medical Case Reports, 2013
Introduction: Autoimmune myelofibrosis is an uncommon hematologic disease characterized by anemia, bone marrow myelofibrosis, and an autoimmune feature. Myelofibrosis is often associated with other conditions, including infections, nutritional/endocrine ...
Edy Hasrouni, Heesun J Rogers, Ali Tabarroki, Valeria Visconte, Fabiola Traina, Manuel Afable, Mikkael A Sekeres, Jaroslaw P Maciejewski, Ramon V Tiu   +8 more
doaj   +2 more sources

Triple immunostaining demonstrates the possible existence of segregated-nucleus-containing atypical monocytes in human primary myelofibrosis bone marrow: a case report [PDF]

Journal of Medical Case Reports
Background Segregated-nucleus-containing atypical monocytes have recently been identified in mice. Segregated-nucleus-containing atypical monocytes are thought to originate from the bone marrow and induce fibrosis in the drug-injured lung.
Shunsuke Homma, Toshie Ogasawara, Michie Suga, Yoshiyasu Nakamura, Katsuya Takenaka, Shoko Marshall, Kiyotaka Kawauchi, Naoki Mori, Hajime Kuroda, Naoya Nakamura, Yohei Miyagi, Atsuko Masunaga   +11 more
doaj   +2 more sources

From primary myelofibrosis to chronic myeloid leukemia, BCR::ABL1+ B‐Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolution [PDF]

eJHaem
The simultaneous detection of BCR::ABL1 and JAK2 V617F was rarely reported and their clonal relationship and dynamic clonal shift were not characterized. Here, we described a unique case with the initial presentation as JAK2 V617F+ primary myelofibrosis,
Devin Wang, Wataru Kamata, Fengxi Ye, M. James You   +3 more
doaj   +2 more sources

Role of molecular alterations in transplantation decisions for patients with primary myelofibrosis. [PDF]

Blood Adv
Luque Paz D, Gagelmann N, Benajiba L, Riou J, Salit R, Orvain C, Schroeder T, Bories C, Gurnari C, Badbaran A, Boyer F, Pagliuca S, Rautenberg C, Tavitian S, Pangiota V, Ianotto JC, Thol F, Cayssials E, Heuser M, Rubio MT, Cassinat B, Daltro de Oliveira R, Sauter C, Maciejewski JP, Reinhardt HC, Scott BL, Ugo V, Kröger N, Kiladjian JJ, Robin M.   +29 more
europepmc   +2 more sources

Case report: Successful use of ruxolitinib to treat interstitial pneumonia as an unusual primary presentation in primary myelofibrosis-two birds with one stone. [PDF]

Front Oncol
Xiao P, Dong Z, Wang Q, Su J, Chen Y, Lin Y.   +5 more
europepmc   +2 more sources

¹⁸F-FDG PET/CT findings in a mucosa-associated lymphoid tissue lymphoma patient coexisting with primary myelofibrosis. [PDF]

Am J Nucl Med Mol Imaging
Han Y, Wu R, Zhang Y, Zhang X, Gao Z.
europepmc   +3 more sources